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hutI hutI hutU hutU hutH hutH hutG hutG ftcD ftcD SGO_1809 SGO_1809 rpoA rpoA purA purA ftsZ ftsZ codY codY SGO_1814 SGO_1814
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
hutIImidazolonepropionase; Identified by match to protein family HMM PF01979; match to protein family HMM PF07969; match to protein family HMM TIGR01224; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (421 aa)    
Predicted Functional Partners:
hutU
Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.
 
 
 0.998
hutH
Histidine ammonia-lyase; Identified by match to protein family HMM PF00221; match to protein family HMM TIGR01225; Belongs to the PAL/histidase family.
 
  
 0.983
hutG
Formimidoylglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family.
 
 
 0.974
ftcD
Glutamate formiminotransferase; Identified by match to protein family HMM PF02971; match to protein family HMM PF07837; match to protein family HMM TIGR02024.
 
 
  0.955
SGO_1809
Conserved hypothetical protein; Identified by match to protein family HMM PF05962.
 
   
 0.698
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
      
 0.626
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
      
 0.617
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
      
 0.585
codY
GTP-sensing transcriptional pleiotropic repressor codY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.
      
 0.575
SGO_1814
Putative regulatory protein; Identified by match to protein family HMM PF03704; match to protein family HMM PF07719.
 
     0.569
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
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