STRINGSTRING
rph rph Caci_5884 Caci_5884 Caci_6780 Caci_6780 Caci_7551 Caci_7551 dnaG dnaG rpsD rpsD Caci_5672 Caci_5672 rpsK rpsK Caci_2659 Caci_2659 Caci_2213 Caci_2213 Caci_6512 Caci_6512
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (243 aa)    
Predicted Functional Partners:
Caci_5884
PFAM: ribonuclease II; KEGG: nca:Noca_2017 ribonuclease II.
   
 0.991
Caci_6780
PFAM: 3'-5' exonuclease; HRDC domain protein; SMART: 3'-5' exonuclease; HRDC domain protein; KEGG: sma:SAV_2231 ribonuclease D.
   
 0.991
Caci_7551
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
    0.986
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
    
 
 0.943
rpsD
Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
  
 0.875
Caci_5672
PFAM: RNA binding S1 domain protein; SMART: RNA binding S1 domain protein; KEGG: sco:SCO1998 30S ribosomal protein S1.
 
 0.866
rpsK
Ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.
  
 0.858
Caci_2659
PFAM: RNA binding S1 domain protein; SMART: RNA binding S1 domain protein; KEGG: cms:CMS_1996 30S ribosomal protein S1.
  
 0.848
Caci_2213
KEGG: sen:SACE_6203 ATP-dependent helicase; TIGRFAM: ATP-dependent helicase HrpA; PFAM: helicase-associated domain protein; protein of unknown function DUF1605; helicase domain protein; SMART: DEAD-like helicases; helicase domain protein; AAA ATPase.
   
 0.820
Caci_6512
KEGG: sma:SAV_6231 ATP-dependent RNA helicase; TIGRFAM: ATP-dependent helicase HrpB; PFAM: Helicase ATP-dependent domain protein; helicase-associated domain protein; helicase domain protein; SMART: DEAD-like helicases; helicase domain protein.
   
 0.820
Your Current Organism:
Catenulispora acidiphila
NCBI taxonomy Id: 479433
Other names: C. acidiphila DSM 44928, Catenulispora acidiphila DSM 44928, Catenulispora acidiphila str. DSM 44928, Catenulispora acidiphila strain DSM 44928
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