node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aflv_2165 | dfrA | Aflv_2165 | Aflv_1454 | 5,10-methylenetetrahydrofolate reductase containing methyltransferase and reductase domains. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.940 |
Aflv_2165 | folD | Aflv_2165 | Aflv_0944 | 5,10-methylenetetrahydrofolate reductase containing methyltransferase and reductase domains. | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.952 |
Aflv_2165 | gcvT | Aflv_2165 | Aflv_0915 | 5,10-methylenetetrahydrofolate reductase containing methyltransferase and reductase domains. | Glycine cleavage system protein T (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine. | 0.960 |
Aflv_2165 | glyA | Aflv_2165 | Aflv_2713 | 5,10-methylenetetrahydrofolate reductase containing methyltransferase and reductase domains. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
Aflv_2165 | thyB | Aflv_2165 | Aflv_1455 | 5,10-methylenetetrahydrofolate reductase containing methyltransferase and reductase domains. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.943 |
Aflv_2431 | Aflv_2607 | Aflv_2431 | Aflv_2607 | Esterase; Related to 5'-nucleotidase/2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. | Protein ushA precursor (two S-layer domains; UDP-sugar hydrolase; 5'-nucleotidase); Belongs to the 5'-nucleotidase family. | 0.925 |
Aflv_2431 | comEB | Aflv_2431 | Aflv_0821 | Esterase; Related to 5'-nucleotidase/2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. | Late competence protein ComEB (DNA binding and uptake). | 0.903 |
Aflv_2431 | tdk | Aflv_2431 | Aflv_2723 | Esterase; Related to 5'-nucleotidase/2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. | Thymidine kinase. | 0.903 |
Aflv_2431 | thyB | Aflv_2431 | Aflv_1455 | Esterase; Related to 5'-nucleotidase/2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.914 |
Aflv_2431 | tmk | Aflv_2431 | Aflv_0025 | Esterase; Related to 5'-nucleotidase/2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.912 |
Aflv_2607 | Aflv_2431 | Aflv_2607 | Aflv_2431 | Protein ushA precursor (two S-layer domains; UDP-sugar hydrolase; 5'-nucleotidase); Belongs to the 5'-nucleotidase family. | Esterase; Related to 5'-nucleotidase/2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. | 0.925 |
Aflv_2607 | comEB | Aflv_2607 | Aflv_0821 | Protein ushA precursor (two S-layer domains; UDP-sugar hydrolase; 5'-nucleotidase); Belongs to the 5'-nucleotidase family. | Late competence protein ComEB (DNA binding and uptake). | 0.903 |
Aflv_2607 | tdk | Aflv_2607 | Aflv_2723 | Protein ushA precursor (two S-layer domains; UDP-sugar hydrolase; 5'-nucleotidase); Belongs to the 5'-nucleotidase family. | Thymidine kinase. | 0.917 |
Aflv_2607 | thyB | Aflv_2607 | Aflv_1455 | Protein ushA precursor (two S-layer domains; UDP-sugar hydrolase; 5'-nucleotidase); Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
Aflv_2607 | tmk | Aflv_2607 | Aflv_0025 | Protein ushA precursor (two S-layer domains; UDP-sugar hydrolase; 5'-nucleotidase); Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.912 |
comEB | Aflv_2431 | Aflv_0821 | Aflv_2431 | Late competence protein ComEB (DNA binding and uptake). | Esterase; Related to 5'-nucleotidase/2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. | 0.903 |
comEB | Aflv_2607 | Aflv_0821 | Aflv_2607 | Late competence protein ComEB (DNA binding and uptake). | Protein ushA precursor (two S-layer domains; UDP-sugar hydrolase; 5'-nucleotidase); Belongs to the 5'-nucleotidase family. | 0.903 |
comEB | tdk | Aflv_0821 | Aflv_2723 | Late competence protein ComEB (DNA binding and uptake). | Thymidine kinase. | 0.931 |
comEB | thyB | Aflv_0821 | Aflv_1455 | Late competence protein ComEB (DNA binding and uptake). | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.940 |
comEB | tmk | Aflv_0821 | Aflv_0025 | Late competence protein ComEB (DNA binding and uptake). | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.930 |