node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BIG1 | CWH41 | YHR101C | YGL027C | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | 0.779 |
BIG1 | KEG1 | YHR101C | YFR042W | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Beta-1,6-glucan synthesis-associated protein KEG1; Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability. | 0.631 |
BIG1 | KNH1 | YHR101C | YDL049C | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Protein with similarity to Kre9p; Kre9p is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance. | 0.696 |
BIG1 | KRE5 | YHR101C | YOR336W | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Killer toxin-resistance protein 5; Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects. | 0.922 |
BIG1 | KRE6 | YHR101C | YPR159W | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Beta-glucan synthesis-associated protein KRE6; Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication; Belongs to the SKN1/KRE6 family. | 0.697 |
BIG1 | KRE9 | YHR101C | YJL174W | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects. | 0.776 |
BIG1 | ROT1 | YHR101C | YMR200W | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Protein ROT1; Molecular chaperone involved in protein folding in ER; mutation causes defects in cell wall synthesis and lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation; transmembrane helix Ser250 is essential for Rot1p to interact with other membrane components and exert its functional role, avoiding exposure of Ser H-bonding group at lipid-exposed surface. | 0.963 |
BIG1 | ROT2 | YHR101C | YBR229C | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; Belongs to the glycosyl hydrolase 31 family. | 0.894 |
BIG1 | SKN1 | YHR101C | YGR143W | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Protein involved in sphingolipid biosynthesis; type II membrane protein; SKN1 has a paralog, KRE6, that arose from the whole genome duplication. | 0.605 |
CWH41 | BIG1 | YGL027C | YHR101C | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | 0.779 |
CWH41 | KAR2 | YGL027C | YJL034W | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Endoplasmic reticulum chaperone BiP; ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p. | 0.862 |
CWH41 | KEG1 | YGL027C | YFR042W | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Beta-1,6-glucan synthesis-associated protein KEG1; Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability. | 0.573 |
CWH41 | KNH1 | YGL027C | YDL049C | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Protein with similarity to Kre9p; Kre9p is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance. | 0.470 |
CWH41 | KRE5 | YGL027C | YOR336W | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Killer toxin-resistance protein 5; Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects. | 0.962 |
CWH41 | KRE6 | YGL027C | YPR159W | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Beta-glucan synthesis-associated protein KRE6; Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication; Belongs to the SKN1/KRE6 family. | 0.755 |
CWH41 | ROT1 | YGL027C | YMR200W | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Protein ROT1; Molecular chaperone involved in protein folding in ER; mutation causes defects in cell wall synthesis and lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation; transmembrane helix Ser250 is essential for Rot1p to interact with other membrane components and exert its functional role, avoiding exposure of Ser H-bonding group at lipid-exposed surface. | 0.816 |
CWH41 | ROT2 | YGL027C | YBR229C | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; Belongs to the glycosyl hydrolase 31 family. | 0.999 |
KAR2 | CWH41 | YJL034W | YGL027C | Endoplasmic reticulum chaperone BiP; ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p. | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | 0.862 |
KAR2 | KRE5 | YJL034W | YOR336W | Endoplasmic reticulum chaperone BiP; ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p. | Killer toxin-resistance protein 5; Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects. | 0.668 |
KAR2 | KRE6 | YJL034W | YPR159W | Endoplasmic reticulum chaperone BiP; ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p. | Beta-glucan synthesis-associated protein KRE6; Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication; Belongs to the SKN1/KRE6 family. | 0.553 |