node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACT1 | ARP4 | YFL039C | YJL081C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | 0.999 |
ACT1 | EAF1 | YFL039C | YDR359C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1; Belongs to the EAF1 family. | 0.998 |
ACT1 | EAF6 | YFL039C | YJR082C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Chromatin modification-related protein EAF6; Subunit of the NuA4 acetyltransferase complex; this complex acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3; Belongs to the EAF6 family. | 0.995 |
ACT1 | EPL1 | YFL039C | YFL024C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Enhancer of polycomb-like protein 1; Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains. | 0.999 |
ACT1 | ESA1 | YFL039C | YOR244W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation. | 0.998 |
ACT1 | HHF1 | YFL039C | YBR009C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity. | 0.970 |
ACT1 | SWC4 | YFL039C | YGR002C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | SWR1-complex protein 4; Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex. | 0.999 |
ACT1 | TRA1 | YFL039C | YHR099W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Transcription-associated protein 1; Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation; Belongs to the PI3/PI4-kinase family. TRA1 subfamily. | 0.994 |
ACT1 | YAF9 | YFL039C | YNL107W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Protein AF-9 homolog; Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain. | 0.995 |
ACT1 | YNG2 | YFL039C | YHR090C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Chromatin modification-related protein YNG2; Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5. | 0.995 |
ARP4 | ACT1 | YJL081C | YFL039C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.999 |
ARP4 | EAF1 | YJL081C | YDR359C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1; Belongs to the EAF1 family. | 0.999 |
ARP4 | EAF6 | YJL081C | YJR082C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Chromatin modification-related protein EAF6; Subunit of the NuA4 acetyltransferase complex; this complex acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3; Belongs to the EAF6 family. | 0.998 |
ARP4 | EPL1 | YJL081C | YFL024C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Enhancer of polycomb-like protein 1; Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains. | 0.999 |
ARP4 | ESA1 | YJL081C | YOR244W | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation. | 0.999 |
ARP4 | HHF1 | YJL081C | YBR009C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity. | 0.953 |
ARP4 | SWC4 | YJL081C | YGR002C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | SWR1-complex protein 4; Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex. | 0.999 |
ARP4 | TRA1 | YJL081C | YHR099W | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Transcription-associated protein 1; Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation; Belongs to the PI3/PI4-kinase family. TRA1 subfamily. | 0.999 |
ARP4 | YAF9 | YJL081C | YNL107W | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Protein AF-9 homolog; Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain. | 0.998 |
ARP4 | YNG2 | YJL081C | YHR090C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Chromatin modification-related protein YNG2; Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5. | 0.999 |