node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BIG1 | CNE1 | YHR101C | YAL058W | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast. | 0.787 |
BIG1 | CWH41 | YHR101C | YGL027C | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | 0.779 |
BIG1 | KRE1 | YHR101C | YNL322C | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor. | 0.601 |
BIG1 | KRE5 | YHR101C | YOR336W | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Killer toxin-resistance protein 5; Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects. | 0.922 |
BIG1 | KRE6 | YHR101C | YPR159W | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Beta-glucan synthesis-associated protein KRE6; Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication; Belongs to the SKN1/KRE6 family. | 0.697 |
BIG1 | KRE9 | YHR101C | YJL174W | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects. | 0.776 |
BIG1 | MNN2 | YHR101C | YBR015C | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; Belongs to the MNN1/MNT family. | 0.620 |
BIG1 | OST3 | YHR101C | YOR085W | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3; Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins; Belongs to the OST3/OST6 family. | 0.656 |
BIG1 | ROT2 | YHR101C | YBR229C | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; Belongs to the glycosyl hydrolase 31 family. | 0.894 |
CNE1 | BIG1 | YAL058W | YHR101C | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast. | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | 0.787 |
CNE1 | CWH41 | YAL058W | YGL027C | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast. | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | 0.992 |
CNE1 | KRE1 | YAL058W | YNL322C | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast. | Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor. | 0.719 |
CNE1 | KRE5 | YAL058W | YOR336W | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast. | Killer toxin-resistance protein 5; Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects. | 0.980 |
CNE1 | KRE6 | YAL058W | YPR159W | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast. | Beta-glucan synthesis-associated protein KRE6; Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication; Belongs to the SKN1/KRE6 family. | 0.659 |
CNE1 | KRE9 | YAL058W | YJL174W | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast. | Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects. | 0.607 |
CNE1 | MNN2 | YAL058W | YBR015C | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast. | Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; Belongs to the MNN1/MNT family. | 0.630 |
CNE1 | OST3 | YAL058W | YOR085W | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast. | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3; Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins; Belongs to the OST3/OST6 family. | 0.889 |
CNE1 | ROT2 | YAL058W | YBR229C | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast. | Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; Belongs to the glycosyl hydrolase 31 family. | 0.969 |
CNE1 | STT3 | YAL058W | YGL022W | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast. | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3; Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis; Belongs to the STT3 family. | 0.831 |
CWH41 | BIG1 | YGL027C | YHR101C | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family. | 0.779 |