node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arcB | barA | b3210 | b2786 | Aerobic respiration control sensor protein ArcB; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576. | Hybrid sensory histidine kinase, in two-component regulatory system with UvrY; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay. | 0.967 |
arcB | evgS | b3210 | b2370 | Aerobic respiration control sensor protein ArcB; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576. | Hybrid sensory histidine kinase in two-component regulatory system with EvgA; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals. | 0.964 |
arcB | sfmZ | b3210 | b0535 | Aerobic respiration control sensor protein ArcB; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576. | Response regulator family protein; Fimbrial Z protein; probable signal transducer; Protein involved in transcription activator activity and transcription. | 0.464 |
arcB | yaiV | b3210 | b0375 | Aerobic respiration control sensor protein ArcB; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576. | Putative transcriptional regulator; Involved in oxidative stress resistance; Belongs to the IprA family. | 0.493 |
barA | arcB | b2786 | b3210 | Hybrid sensory histidine kinase, in two-component regulatory system with UvrY; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay. | Aerobic respiration control sensor protein ArcB; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576. | 0.967 |
barA | evgS | b2786 | b2370 | Hybrid sensory histidine kinase, in two-component regulatory system with UvrY; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay. | Hybrid sensory histidine kinase in two-component regulatory system with EvgA; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals. | 0.955 |
barA | sfmZ | b2786 | b0535 | Hybrid sensory histidine kinase, in two-component regulatory system with UvrY; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay. | Response regulator family protein; Fimbrial Z protein; probable signal transducer; Protein involved in transcription activator activity and transcription. | 0.432 |
barA | yaiV | b2786 | b0375 | Hybrid sensory histidine kinase, in two-component regulatory system with UvrY; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay. | Putative transcriptional regulator; Involved in oxidative stress resistance; Belongs to the IprA family. | 0.462 |
ebgC | ibsD | b3077 | b4664 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Toxic membrane protein. | 0.523 |
ebgC | narV | b3077 | b1465 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Nitrate reductase 2 (NRZ), gamma subunit; This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit. | 0.400 |
ebgC | yaiV | b3077 | b0375 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Putative transcriptional regulator; Involved in oxidative stress resistance; Belongs to the IprA family. | 0.531 |
ebgC | ygcW | b3077 | b2774 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.519 |
ebgC | ygeG | b3077 | b2851 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Uncharacterized protein YgeG; Pseudogene; Belongs to the LcrH/SycD chaperone family. | 0.538 |
evgS | arcB | b2370 | b3210 | Hybrid sensory histidine kinase in two-component regulatory system with EvgA; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals. | Aerobic respiration control sensor protein ArcB; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576. | 0.964 |
evgS | barA | b2370 | b2786 | Hybrid sensory histidine kinase in two-component regulatory system with EvgA; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals. | Hybrid sensory histidine kinase, in two-component regulatory system with UvrY; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay. | 0.955 |
evgS | yaiV | b2370 | b0375 | Hybrid sensory histidine kinase in two-component regulatory system with EvgA; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals. | Putative transcriptional regulator; Involved in oxidative stress resistance; Belongs to the IprA family. | 0.455 |
ibsD | ebgC | b4664 | b3077 | Toxic membrane protein. | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | 0.523 |
ibsD | narV | b4664 | b1465 | Toxic membrane protein. | Nitrate reductase 2 (NRZ), gamma subunit; This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit. | 0.478 |
ibsD | yaiV | b4664 | b0375 | Toxic membrane protein. | Putative transcriptional regulator; Involved in oxidative stress resistance; Belongs to the IprA family. | 0.620 |
ibsD | ygcW | b4664 | b2774 | Toxic membrane protein. | Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.529 |