node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
chbR | nagC | b1735 | b0676 | Repressor of chb operon for N,N'-diacetylchitobiose utilization; Dual-function repressor/activator of the chbBCARFG operon. In the absence of the inducing sugar chitobiose, together with NagC, represses the chbBCARFG operon for the uptake and metabolism of chitobiose. In association with Crp, and probably in the presence of chitobiose 6-phosphate, induces the transcription of the chbBCARFG operon. | N-acetylglucosamine-inducible nag divergent operon transcriptional repressor; Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon. Belongs to the ROK (NagC/XylR) family. | 0.808 |
fimB | nagC | b4312 | b0676 | Tyrosine recombinase/inversion of on/off regulator of fimA; FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, FimA. FimB switches FimA on. | N-acetylglucosamine-inducible nag divergent operon transcriptional repressor; Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon. Belongs to the ROK (NagC/XylR) family. | 0.623 |
fimB | nanR | b4312 | b3226 | Tyrosine recombinase/inversion of on/off regulator of fimA; FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, FimA. FimB switches FimA on. | Sialic acid-inducible nan operon repressor; Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids. Represses expression of the nanATEK- yhcH, nanCMS and yjhBC operons. Acts by binding directly to the Nan box, a region of approximately 30 bp covering the promoter region. | 0.644 |
glmS | glmU | b3729 | b3730 | L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.998 |
glmS | nagA | b3729 | b0677 | L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | 0.960 |
glmS | nagB | b3729 | b0678 | L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. | 0.976 |
glmS | nagC | b3729 | b0676 | L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | N-acetylglucosamine-inducible nag divergent operon transcriptional repressor; Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon. Belongs to the ROK (NagC/XylR) family. | 0.643 |
glmS | nagE | b3729 | b0679 | L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | N-acetyl glucosamine specific PTS enzyme IIC, IIB, and IIA components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport. It can also transport and phosphorylate the antibiotic streptozotocin. Could play a significant role in the recycling of peptidoglycan. | 0.594 |
glmU | glmS | b3730 | b3729 | Fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.998 |
glmU | nagA | b3730 | b0677 | Fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | 0.649 |
glmU | nagB | b3730 | b0678 | Fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. | 0.679 |
glmU | nagC | b3730 | b0676 | Fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | N-acetylglucosamine-inducible nag divergent operon transcriptional repressor; Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon. Belongs to the ROK (NagC/XylR) family. | 0.647 |
glmU | nagE | b3730 | b0679 | Fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | N-acetyl glucosamine specific PTS enzyme IIC, IIB, and IIA components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport. It can also transport and phosphorylate the antibiotic streptozotocin. Could play a significant role in the recycling of peptidoglycan. | 0.563 |
gntR | nagC | b3438 | b0676 | D-gluconate inducible gluconate regulon transcriptional repressor; Negative regulator for the gluconate utilization system GNT- I, the gntUKR operon. | N-acetylglucosamine-inducible nag divergent operon transcriptional repressor; Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon. Belongs to the ROK (NagC/XylR) family. | 0.567 |
gntR | nanR | b3438 | b3226 | D-gluconate inducible gluconate regulon transcriptional repressor; Negative regulator for the gluconate utilization system GNT- I, the gntUKR operon. | Sialic acid-inducible nan operon repressor; Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids. Represses expression of the nanATEK- yhcH, nanCMS and yjhBC operons. Acts by binding directly to the Nan box, a region of approximately 30 bp covering the promoter region. | 0.737 |
nagA | glmS | b0677 | b3729 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.960 |
nagA | glmU | b0677 | b3730 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | Fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.649 |
nagA | nagB | b0677 | b0678 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. | 0.999 |
nagA | nagC | b0677 | b0676 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | N-acetylglucosamine-inducible nag divergent operon transcriptional repressor; Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon. Belongs to the ROK (NagC/XylR) family. | 0.994 |
nagA | nagE | b0677 | b0679 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | N-acetyl glucosamine specific PTS enzyme IIC, IIB, and IIA components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport. It can also transport and phosphorylate the antibiotic streptozotocin. Could play a significant role in the recycling of peptidoglycan. | 0.996 |