STRINGSTRING
uidR uidR uidA uidA uxuR uxuR malI malI exuR exuR lgoR lgoR lgoD lgoD hdhA hdhA evgS evgS uidB uidB ypjA ypjA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
uidRTranscriptional repressor; Repressor for the uidRABC (gusRABC) operon. (196 aa)    
Predicted Functional Partners:
uidA
beta-D-glucuronidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family.
  
  
 0.934
uxuR
Fructuronate-inducible hexuronate regulon transcriptional repressor; Repressor for the uxuRBA operon.
   
  
 0.880
malI
Transcriptional repressor of Mal regulon; Repressor for the malX and malY genes. Also regulates its own expression. Binds maltose as an inducer.
  
  
 0.712
exuR
Hexuronate regulon transcriptional repressor; Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers.
   
  
 0.658
lgoR
Putative transcriptional activator for L-galactonate catabolism; May be a positive transcriptional regulator for lgoD and/or lgoT. Is essential for growth on L-galactonate as the sole carbon source.
   
  
 0.643
lgoD
L-galactonate oxidoreductase; Catalyzes the oxidation of L-galactonate to D-tagaturonate. Required for growth on L-galactonate as the sole carbon source. In vitro, can also use L-gulonate.
      
 0.541
hdhA
7-alpha-hydroxysteroid dehydrogenase, NAD-dependent; Catalyzes the oxidation of the 7-alpha-hydroxy group of primary bile acids such as cholate, chenodeoxycholate and taurochenodeoxycholate. To a lesser extent, also able to use taurocholate and glycocholate.
     
 0.528
evgS
Hybrid sensory histidine kinase in two-component regulatory system with EvgA; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals.
  
 
 
 0.493
uidB
Glucuronide permease; Protein involved in carbohydrate catabolic process.
 
     0.461
ypjA
Adhesin-like autotransporter; Putative ATP-binding component of a transport system.
  
   
 0.458
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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