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oxc oxc frc frc yfdV yfdV yfdE yfdE yfdX yfdX ydeP ydeP ydeO ydeO ilvH ilvH emrK emrK emrY emrY yhjX yhjX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
oxcOxalyl CoA decarboxylase, ThDP-dependent; Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the decarboxylation of oxalyl-CoA to yield carbon dioxide and formyl-CoA; Belongs to the TPP enzyme family. (564 aa)    
Predicted Functional Partners:
frc
formyl-CoA transferase, NAD(P)-binding; Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl- CoA to oxalate. It can also use succinate as an acceptor.
 
 
 0.999
yfdV
Putative receptor protein.
 
  
 0.996
yfdE
acetyl-CoA:oxalate CoA-transferase; Involved in the catabolism of oxalate and in the adapatation to low pH. ACOCT serves to prime the oxalate-induced acid tolerance response (ATR) cycle by producing substrate for oxalyl-CoA decarboxylase (OXC) and formyl-coenzyme A transferase (FCOCT). Catalyzes the reversible conversion of acetyl-CoA and oxalate to oxalyl-CoA and acetate. It can also use formyl-CoA and oxalate to produce oxalyl-CoA and formate with significantly reduced specific activity.
 
 
 0.994
yfdX
Uncharacterized protein.
   
  
 0.976
ydeP
Putative oxidoreductase; Probably involved in acid resistance. Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
   
  
 0.844
ydeO
UV-inducible global regulator, EvgA-, GadE-dependent; Induces the expression of gadE and mdtEF. Could also regulate the expression of other genes involved in acid resistance.
   
  
 0.807
ilvH
Acetolactate synthase III, valine sensitive, small subunit.
 
 0.800
emrK
Multidrug resistance efflux pump membrane fusion protein; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs.
   
  
 0.759
emrY
Putative multidrug efflux system; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs.
   
    0.753
yhjX
Pyruvate-inducible inner membrane protein, putative transporter; Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their respective target proteins, BtsT and YhjX. Belongs to the major facilitator superfamily.
  
   
 0.743
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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