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mntH mntH mntR mntR zupT zupT mntP mntP feoB feoB sodA sodA oxyR oxyR znuB znuB mgtA mgtA hemH hemH fieF fieF
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mntHManganese/divalent cation transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen. (412 aa)    
Predicted Functional Partners:
mntR
Mn(2+)-responsive manganese regulon transcriptional regulator; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP.
 
  
 0.951
zupT
Zinc transporter; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions; Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
  
  
 0.929
mntP
Putative Mn(2+) efflux pump, mntR-regulated; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family.
      
 0.910
feoB
Ferrous iron transporter protein B and GTP-binding protein; Transporter of a GTP-driven Fe(2+) uptake system, probably couples GTP-binding to channel opening and Fe(2+) uptake. A guanine nucleotide-binding protein (G proteins) in which the guanine nucleotide binding site alternates between an active, GTP-bound state and an inactive, GDP- bound state. This protein has fast intrinsic GDP release, mediated by the G5 loop (about residues 149-158). Presumably GTP hydrolysis leads to conformational changes and channel closing. A GDP release mechanism involving a conformational change of the [...]
   
  
 0.856
sodA
Superoxide dismutase, Mn; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family.
   
  
 0.813
oxyR
Oxidative and nitrosative stress transcriptional regulator; Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto- [...]
      
 0.808
znuB
Zinc ABC transporter permease; Involved in the high-affinity zinc uptake transport system; Belongs to the ABC-3 integral membrane protein family.
   
  
 0.701
mgtA
Magnesium transporter; Mediates magnesium influx to the cytosol. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
 
 
 0.701
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family.
  
  
 0.694
fieF
Ferrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
   
 
 0.677
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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