node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gpt | gsk | b0238 | b0477 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | 0.978 |
gpt | guaA | b0238 | b2507 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.990 |
gpt | guaB | b0238 | b2508 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.970 |
gpt | guaC | b0238 | b0104 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. | 0.970 |
gpt | hpt | b0238 | b0125 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine. Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.985 |
gpt | purA | b0238 | b4177 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.611 |
gpt | purB | b0238 | b1131 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | Adenylosuccinate lyase; Protein involved in purine nucleotide biosynthetic process; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.618 |
gpt | purH | b0238 | b4006 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | IMP cyclohydrolase and phosphoribosylaminoimidazolecarboxamide formyltransferase; Protein involved in purine nucleotide biosynthetic process and nucleobase, nucleoside and nucleotide interconversion. | 0.557 |
gpt | rdgB | b0238 | b2954 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Can also efficiently hydrolyze 2'- deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP). Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. To a much lesser extent, is als [...] | 0.915 |
gpt | umpG | b0238 | b2744 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | Broad specificity 5'(3')-nucleotidase and polyphosphatase; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays [...] | 0.914 |
gsk | gpt | b0477 | b0238 | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | 0.978 |
gsk | guaA | b0477 | b2507 | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.928 |
gsk | guaB | b0477 | b2508 | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.953 |
gsk | guaC | b0477 | b0104 | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. | 0.931 |
gsk | hpt | b0477 | b0125 | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine. Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.959 |
gsk | purA | b0477 | b4177 | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.949 |
gsk | purB | b0477 | b1131 | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | Adenylosuccinate lyase; Protein involved in purine nucleotide biosynthetic process; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.489 |
gsk | purH | b0477 | b4006 | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | IMP cyclohydrolase and phosphoribosylaminoimidazolecarboxamide formyltransferase; Protein involved in purine nucleotide biosynthetic process and nucleobase, nucleoside and nucleotide interconversion. | 0.915 |
gsk | umpG | b0477 | b2744 | Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. | Broad specificity 5'(3')-nucleotidase and polyphosphatase; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays [...] | 0.900 |
guaA | gpt | b2507 | b0238 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. | 0.990 |