STRINGSTRING
exuT exuT exuR exuR uxaC uxaC uxaA uxaA uxaB uxaB uxuR uxuR uxuA uxuA uxuB uxuB rhaT rhaT ecpD ecpD araF araF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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[Homology]
Score
exuTHexuronate transporter; Aldohexuronate transport system. (432 aa)    
Predicted Functional Partners:
exuR
Hexuronate regulon transcriptional repressor; Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers.
 
  
 0.976
uxaC
Uronate isomerase; Protein involved in carbohydrate catabolic process; Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
 
  
 0.928
uxaA
Altronate hydrolase; Catalyzes the dehydration of D-altronate.
  
 0.920
uxaB
Altronate oxidoreductase, NAD-dependent; Altronate oxidoreductase; Protein involved in carbohydrate catabolic process.
  
  
 0.909
uxuR
Fructuronate-inducible hexuronate regulon transcriptional repressor; Repressor for the uxuRBA operon.
  
   
 0.857
uxuA
Mannonate hydrolase; Catalyzes the dehydration of D-mannonate.
  
  
 0.826
uxuB
D-mannonate oxidoreductase, NAD-dependent; D-mannonate oxidoreductase; Protein involved in carbohydrate catabolic process; Belongs to the mannitol dehydrogenase family. UxuB subfamily.
   
  
 0.810
rhaT
L-rhamnose:proton symporter; Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-mannose and L-xylose, but at reduced rates.
  
     0.529
ecpD
Polymerized tip adhesin of ECP fibers; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Tip pilus adhesin, which is required for assembly of EcpA into fibers (By similarity).
      
 0.500
araF
L-arabinose ABC transporter periplasmic binding protein; Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D- galactose (approximately 2-fold reduction) and D-fucose (approximately 40-fold reduction).
  
  
 0.497
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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