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yjjJ yjjJ yjjI yjjI psuT psuT hipB hipB frlA frlA ypdC ypdC yggD yggD yeeY yeeY yhjB yhjB yfjR yfjR deoD deoD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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yjjJPutative protein kinase; Toxic when overexpressed in E.coli, leading to long filamentous cells. The toxic effect is neutralized by non-cognate antitoxin HipB. Does not seem to inhibit DNA, RNA or protein synthesis, and unlike paralogous toxin HipA its toxic activity is not counteracted by overexpression of GltX. Binds DNA. Might be a protein kinase (By similarity). (443 aa)    
Predicted Functional Partners:
yjjI
DUF3029 family protein, putative glycine radical enzyme.
     
 0.659
psuT
Putative nucleoside transporter; Could be involved in pseudouridine transport; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
      
 0.644
hipB
Antitoxin of HipAB toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the toxic effect of cognate toxin HipA. Also neutralizes the toxic effect of non-cognate toxin YjjJ. Binds to operator sites with the consensus sequence 5-'TATCCN(8)GGATA-3' to repress the hipBA operon promoter ; binding of HipB(2) to DNA induces a 70 degree bend. This forces HipA dimerization, which blocks HipA's active site and thus its toxic action. May play a role in biofilm formation.
     
 0.556
frlA
Putative fructoselysine transporter; Is likely involved in the transport of fructoselysine and psicoselysine to the cytoplasm, where they are degraded.
   
  
 0.531
ypdC
Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription.
      
 0.528
yggD
MtlR family putative transcriptional repressor; In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate; Belongs to the MtlR/FumE family.
      
 0.528
yeeY
Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family.
      
 0.521
yhjB
Putative DNA-binding transcriptional response regulator; Putative regulator; Protein involved in transcription activator activity and transcription.
      
 0.519
yfjR
CP4-57 prophage; putative DNA-binding transcriptional regulator.
   
  
 0.513
deoD
Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules.
       0.501
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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