STRINGSTRING
hokC hokC hokA hokA hokB hokB hokE hokE ybcO ybcO yfdT yfdT tus tus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hokCSmall toxic membrane polypeptide; completely contained in another CDS. (50 aa)    
Predicted Functional Partners:
hokA
Protein HokA; Toxic component of a type I toxin-antitoxin (TA) system (Probable). When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration. Its toxic effect is probably neutralized by antisense antitoxin RNA SokA. Belongs to the Hok/Gef family.
      
 0.874
hokB
Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system (Probable). When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration. Expression leads to membrane depolarization; when protein levels are high enough depolarization probably leads to lowered metabolic activity which in turn induces some cells to enter the persistent state in which they transiently survive antibiotic exposure. Its toxic effect is probably neutralized by antisense antitoxin RNA SokB, which is encoded in trans on the opposite DN [...]
   
  
 0.821
hokE
Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system; if it expressed it could be neutralized by antisense antitoxin RNA SokE. Belongs to the Hok/Gef family.
      
 0.803
ybcO
DLP12 prophage; Based on its fold and a conserved His residue, has been predicted to be a nuclease; Belongs to the YbcO family.
      
 0.528
yfdT
CPS-53 (KpLE1) prophage; uncharacterized protein.
      
 0.451
tus
Inhibitor of replication at Ter, DNA-binding protein; Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
      
 0.432
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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