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thiM thiM thiE thiE Mpal_1249 Mpal_1249 Mpal_0478 Mpal_0478 Mpal_1221 Mpal_1221 Mpal_0416 Mpal_0416 thiC thiC Mpal_1218 Mpal_1218 cofH cofH Mpal_0411 Mpal_0411 cofG cofG
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (265 aa)    
Predicted Functional Partners:
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
Mpal_1249
TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: mem:Memar_1226 phosphomethylpyrimidine kinase.
  
 0.993
Mpal_0478
Conserved hypothetical protein; KEGG: mem:Memar_1460 phosphomethylpyrimidine kinase.
    
 0.904
Mpal_1221
KEGG: mba:Mbar_A3238 hypothetical protein.
    
 0.904
Mpal_0416
PFAM: thiamine biosynthesis protein ThiC; KEGG: mem:Memar_0053 thiamine biosynthesis protein ThiC.
  
  
 0.688
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.688
Mpal_1218
PFAM: thiamineS protein; KEGG: mla:Mlab_0969 hypothetical protein.
  
    0.686
cofH
Radical SAM domain protein; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine.
  
  
 0.576
Mpal_0411
PFAM: Radical SAM domain protein; KEGG: mbn:Mboo_0038 radical SAM domain-containing protein.
  
  
 0.576
cofG
Radical SAM domain protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
  
  
 0.576
Your Current Organism:
Methanosphaerula palustris
NCBI taxonomy Id: 521011
Other names: Candidatus Methanosphaerula palustris E1-9c, M. palustris E1-9c, Methanosphaerula palustris E1-9c, Methanosphaerula palustris str. E1-9c, Methanosphaerula palustris strain E1-9c
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