node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TON_0678 | TON_0881 | TON_0678 | TON_0881 | hisC histidinol-phosphate aminotransferase. | Imidazoleglycerol-phosphate dehydratase. | 0.988 |
TON_0678 | hisA | TON_0678 | TON_0883 | hisC histidinol-phosphate aminotransferase. | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. | 0.868 |
TON_0678 | hisC | TON_0678 | TON_0886 | hisC histidinol-phosphate aminotransferase. | Hypothetical histidinol-phosphate aminotransferase. | 0.915 |
TON_0678 | hisD | TON_0678 | TON_0880 | hisC histidinol-phosphate aminotransferase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.895 |
TON_0678 | hisF | TON_0678 | TON_0884 | hisC histidinol-phosphate aminotransferase. | Imidazoleglycerol-phosphate synthase, cyclase subunit F; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.882 |
TON_0678 | hisG | TON_0678 | TON_0879 | hisC histidinol-phosphate aminotransferase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.881 |
TON_0678 | hisH | TON_0678 | TON_0882 | hisC histidinol-phosphate aminotransferase. | Imidazoleglycerol-phosphate synthase, subunit H; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.890 |
TON_0678 | hisI | TON_0678 | TON_0885 | hisC histidinol-phosphate aminotransferase. | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.992 |
TON_0878 | TON_0881 | TON_0878 | TON_0881 | ATP phosphoribosyltransferase; Predicted regulatory subunit. | Imidazoleglycerol-phosphate dehydratase. | 0.859 |
TON_0878 | TON_0887 | TON_0878 | TON_0887 | ATP phosphoribosyltransferase; Predicted regulatory subunit. | Hypothetical hydrolase; HAD superfamily. | 0.815 |
TON_0878 | hisA | TON_0878 | TON_0883 | ATP phosphoribosyltransferase; Predicted regulatory subunit. | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. | 0.881 |
TON_0878 | hisC | TON_0878 | TON_0886 | ATP phosphoribosyltransferase; Predicted regulatory subunit. | Hypothetical histidinol-phosphate aminotransferase. | 0.824 |
TON_0878 | hisD | TON_0878 | TON_0880 | ATP phosphoribosyltransferase; Predicted regulatory subunit. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.857 |
TON_0878 | hisF | TON_0878 | TON_0884 | ATP phosphoribosyltransferase; Predicted regulatory subunit. | Imidazoleglycerol-phosphate synthase, cyclase subunit F; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.864 |
TON_0878 | hisG | TON_0878 | TON_0879 | ATP phosphoribosyltransferase; Predicted regulatory subunit. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.996 |
TON_0878 | hisH | TON_0878 | TON_0882 | ATP phosphoribosyltransferase; Predicted regulatory subunit. | Imidazoleglycerol-phosphate synthase, subunit H; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.841 |
TON_0878 | hisI | TON_0878 | TON_0885 | ATP phosphoribosyltransferase; Predicted regulatory subunit. | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.996 |
TON_0881 | TON_0678 | TON_0881 | TON_0678 | Imidazoleglycerol-phosphate dehydratase. | hisC histidinol-phosphate aminotransferase. | 0.988 |
TON_0881 | TON_0878 | TON_0881 | TON_0878 | Imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Predicted regulatory subunit. | 0.859 |
TON_0881 | TON_0887 | TON_0881 | TON_0887 | Imidazoleglycerol-phosphate dehydratase. | Hypothetical hydrolase; HAD superfamily. | 0.820 |