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tmk tmk thyA thyA ndk ndk surE surE dcd dcd ADG12971.1 ADG12971.1 ADG13524.1 ADG13524.1 rpl10 rpl10 ADG14084.1 ADG14084.1 rfcL rfcL ADG13526.1 ADG13526.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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tmkTIGRFAM: thymidylate kinase; KEGG: mja:MJ0293 thymidylate kinase; PFAM: thymidylate kinase. (184 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase, methanogen type; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
  
 
 0.952
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
  
 
 0.937
surE
Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
 
  
 0.932
dcd
Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
  
 
 0.928
ADG12971.1
PFAM: deoxyUTP pyrophosphatase; KEGG: mja:MJ1102 deoxycytidine triphosphate deaminase, putative (dcd).
  
 
 0.925
ADG13524.1
KEGG: mfe:Mefer_0666 putative signal transduction protein with CBS domains; PFAM: CBS domain containing protein; SMART: CBS domain containing protein.
     
 0.888
rpl10
Ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.
  
  
 0.811
ADG14084.1
KEGG: mfe:Mefer_0047 6-pyruvoyl tetrahydropterin synthase.
     
 0.730
rfcL
AAA ATPase central domain protein; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily.
  
 
 0.724
ADG13526.1
KEGG: mja:MJ0292 putative monovalent cation/H+ antiporter subunit G.
       0.724
Your Current Organism:
Methanocaldococcus infernus
NCBI taxonomy Id: 573063
Other names: M. infernus ME, Methanocaldococcus infernus DSM 11812, Methanocaldococcus infernus ME, Methanocaldococcus infernus str. ME, Methanocaldococcus infernus strain ME
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