node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fumA | fumB | ECIAI1_1663 | ECIAI1_4352 | Fumarate hydratase (fumarase A), aerobic Class I; Function experimentally demonstrated in the studied species; enzyme. | Anaerobic class I fumarate hydratase (fumarase B); Function experimentally demonstrated in the studied species; enzyme. | 0.948 |
fumA | gcvP | ECIAI1_1663 | ECIAI1_3022 | Fumarate hydratase (fumarase A), aerobic Class I; Function experimentally demonstrated in the studied species; enzyme. | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.935 |
fumB | fumA | ECIAI1_4352 | ECIAI1_1663 | Anaerobic class I fumarate hydratase (fumarase B); Function experimentally demonstrated in the studied species; enzyme. | Fumarate hydratase (fumarase A), aerobic Class I; Function experimentally demonstrated in the studied species; enzyme. | 0.948 |
fumB | gcvP | ECIAI1_4352 | ECIAI1_3022 | Anaerobic class I fumarate hydratase (fumarase B); Function experimentally demonstrated in the studied species; enzyme. | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.935 |
gcvH | gcvP | ECIAI1_3023 | ECIAI1_3022 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | ECIAI1_3023 | ECIAI1_3024 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | gltB | ECIAI1_3023 | ECIAI1_3360 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glutamate synthase, large subunit; Function experimentally demonstrated in the studied species; enzyme. | 0.928 |
gcvH | glyA | ECIAI1_3023 | ECIAI1_2604 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.963 |
gcvH | lpd | ECIAI1_3023 | ECIAI1_0114 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoamide dehydrogenase, E3 component is part of three enzyme complexes; Function experimentally demonstrated in the studied species; enzyme. | 0.972 |
gcvP | fumA | ECIAI1_3022 | ECIAI1_1663 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Fumarate hydratase (fumarase A), aerobic Class I; Function experimentally demonstrated in the studied species; enzyme. | 0.935 |
gcvP | fumB | ECIAI1_3022 | ECIAI1_4352 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Anaerobic class I fumarate hydratase (fumarase B); Function experimentally demonstrated in the studied species; enzyme. | 0.935 |
gcvP | gcvH | ECIAI1_3022 | ECIAI1_3023 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
gcvP | gcvT | ECIAI1_3022 | ECIAI1_3024 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvP | gltB | ECIAI1_3022 | ECIAI1_3360 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glutamate synthase, large subunit; Function experimentally demonstrated in the studied species; enzyme. | 0.989 |
gcvP | glyA | ECIAI1_3022 | ECIAI1_2604 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
gcvP | kbl | ECIAI1_3022 | ECIAI1_3790 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine C-acetyltransferase; Function experimentally demonstrated in the studied species; enzyme. | 0.933 |
gcvP | lpd | ECIAI1_3022 | ECIAI1_0114 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Lipoamide dehydrogenase, E3 component is part of three enzyme complexes; Function experimentally demonstrated in the studied species; enzyme. | 0.987 |
gcvP | ltaE | ECIAI1_3022 | ECIAI1_0910 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | L-allo-threonine aldolase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. | 0.958 |
gcvP | purD | ECIAI1_3022 | ECIAI1_4220 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase; Function experimentally demonstrated in the studied species; enzyme. | 0.949 |
gcvT | gcvH | ECIAI1_3024 | ECIAI1_3023 | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |