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gcvP gcvP gcvH gcvH gcvT gcvT glyA glyA gltB gltB lpd lpd ltaE ltaE purD purD fumA fumA fumB fumB kbl kbl
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
gcvPGlycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)    
Predicted Functional Partners:
gcvH
Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
gcvT
Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine.
 0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.996
gltB
Glutamate synthase, large subunit; Function experimentally demonstrated in the studied species; enzyme.
   
 0.989
lpd
Lipoamide dehydrogenase, E3 component is part of three enzyme complexes; Function experimentally demonstrated in the studied species; enzyme.
 
 
 0.987
ltaE
L-allo-threonine aldolase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme.
    
 0.958
purD
Phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase; Function experimentally demonstrated in the studied species; enzyme.
  
  
 0.949
fumA
Fumarate hydratase (fumarase A), aerobic Class I; Function experimentally demonstrated in the studied species; enzyme.
   
    0.935
fumB
Anaerobic class I fumarate hydratase (fumarase B); Function experimentally demonstrated in the studied species; enzyme.
   
    0.935
kbl
Glycine C-acetyltransferase; Function experimentally demonstrated in the studied species; enzyme.
  
 
 0.933
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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