STRINGSTRING
ADB46865.1 ADB46865.1 thiE thiE thiM thiM thiC thiC ADB47561.1 ADB47561.1 ADB46867.1 ADB46867.1 ADB46864.1 ADB46864.1 ADB47636.1 ADB47636.1 ffh ffh ADB46868.1 ADB46868.1 ADB47385.1 ADB47385.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ADB46865.1TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: esi:Exig_0540 phosphomethylpyrimidine kinase. (274 aa)    
Predicted Functional Partners:
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
  
 0.987
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
 
 0.984
ADB47561.1
PFAM: thiamine monophosphate synthase; KEGG: ere:EUBREC_0222 thiamine-phosphate pyrophosphorylase, putative.
 
 
 0.927
ADB46867.1
Hypothetical protein.
       0.752
ADB46864.1
Transketolase; KEGG: pmx:PERMA_1704 transketolase; TIGRFAM: transketolase; PFAM: Transketolase domain protein; Transketolase central region; Belongs to the transketolase family.
     
 0.645
ADB47636.1
PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; KEGG: cdf:CD2335 inosine 5-monophosphate dehydrogenase.
   
 
 0.564
ffh
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
  
    0.552
ADB46868.1
Putative helix-turn-helix protein YlxM/p13 family protein; Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.
       0.545
ADB47385.1
PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; DbpA RNA-binding domain protein; SMART: DEAD-like helicase; helicase domain protein; KEGG: dsy:DSY1954 hypothetical protein.
 
 
   0.509
Your Current Organism:
Acidaminococcus fermentans
NCBI taxonomy Id: 591001
Other names: A. fermentans DSM 20731, Acidaminococcus fermentans DSM 20731, Acidaminococcus fermentans str. DSM 20731, Acidaminococcus fermentans strain DSM 20731
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