node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dcd | hisG | TGAM_0490 | TGAM_1607 | Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. | ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.420 |
dcd | ndk | TGAM_0490 | TGAM_1873 | Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.933 |
dcd | nrdA | TGAM_0490 | TGAM_0422 | Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. | Ribonucleoside-diphosphate reductase alpha subunit (nrdA); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.426 |
dcd | nrdD | TGAM_0490 | TGAM_0161 | Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. | Anaerobic ribonucleoside triphosphate reductase (nrdD). | 0.919 |
dcd | pyrE | TGAM_0490 | TGAM_1900 | Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. | Orotate phosphoribosyltransferase (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.501 |
dcd | pyrG | TGAM_0490 | TGAM_1661 | Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. | CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.932 |
dcd | thyX | TGAM_0490 | TGAM_1151 | Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. | Thymidylate synthase, flavin-dependent (thyX); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.429 |
dcd | tmk | TGAM_0490 | TGAM_1769 | Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. | Thymidylate kinase (dTMP kinase) (tmk). | 0.579 |
dcd | tpiA | TGAM_0490 | TGAM_0313 | Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. | Triosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.406 |
hisG | dcd | TGAM_1607 | TGAM_0490 | ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. | 0.420 |
ndk | dcd | TGAM_1873 | TGAM_0490 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. | 0.933 |
ndk | nrdA | TGAM_1873 | TGAM_0422 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | Ribonucleoside-diphosphate reductase alpha subunit (nrdA); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.929 |
ndk | nrdD | TGAM_1873 | TGAM_0161 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | Anaerobic ribonucleoside triphosphate reductase (nrdD). | 0.922 |
ndk | pyrE | TGAM_1873 | TGAM_1900 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | Orotate phosphoribosyltransferase (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.422 |
ndk | pyrG | TGAM_1873 | TGAM_1661 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.947 |
ndk | tmk | TGAM_1873 | TGAM_1769 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | Thymidylate kinase (dTMP kinase) (tmk). | 0.942 |
ndk | tpiA | TGAM_1873 | TGAM_0313 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | Triosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.560 |
nrdA | dcd | TGAM_0422 | TGAM_0490 | Ribonucleoside-diphosphate reductase alpha subunit (nrdA); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. | 0.426 |
nrdA | ndk | TGAM_0422 | TGAM_1873 | Ribonucleoside-diphosphate reductase alpha subunit (nrdA); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.929 |
nrdA | nrdD | TGAM_0422 | TGAM_0161 | Ribonucleoside-diphosphate reductase alpha subunit (nrdA); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Anaerobic ribonucleoside triphosphate reductase (nrdD). | 0.516 |