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psmB-2 psmB-2 psmB-1 psmB-1 psmA psmA TGAM_2050 TGAM_2050 TGAM_2051 TGAM_2051 pan pan TGAM_0471 TGAM_0471 prs prs fecE-2 fecE-2 fecD-2 fecD-2 glpK-1 glpK-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
psmB-2Peptidase T1A, 20S proteasome beta-subunit (psmB); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (200 aa)    
Predicted Functional Partners:
psmB-1
Peptidase T1A, 20S proteasome beta-subunit (psmB); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
  
 
0.904
psmA
Peptidase T1A, 20S proteasome alpha-subunit (psmA); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.800
TGAM_2050
Conserved hypothetical protein; 6 probable transmembrane helices predicted by modhmm.
       0.799
TGAM_2051
Conserved hypothetical protein; Belongs to DUF437 family.
       0.799
pan
ATP-dependent 26S proteasome regulatory subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP bindin [...]
  
 0.769
TGAM_0471
Metal-dependant protease, putative; Belongs to Mov34/MPN/PAD-1 family Contains Jab1/MPN domain.
   
 0.735
prs
Ribose-phosphate pyrophosphokinase (prs); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
   
 
 0.674
fecE-2
Iron(III) dicitrate ABC transporter, ATP-binding protein (fecE).
       0.669
fecD-2
Iron(III) dicitrate transport system permease protein (fecD); 8 probable transmembrane helices predicted by modhmm.
       0.669
glpK-1
Glycerol kinase (glpK).
   
 0.612
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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