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purH purH purN purN AAZ58486.1 AAZ58486.1 glyA glyA AAZ58312.1 AAZ58312.1 purT purT purA purA folD folD purM purM purD purD purC purC
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query proteins and first shell of interactors
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second shell of interactors
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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purHIMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase; Alternative locus ID: NATL2_03241. (518 aa)    
Predicted Functional Partners:
purN
Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 0.998
AAZ58486.1
Adenylosuccinate lyase; Alternative locus ID: NATL2_18071; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.992
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.990
AAZ58312.1
Phosphoribosylglycinamide formyltransferase; Alternative locus ID: NATL2_16091.
 
 0.984
purT
Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
   
 
 0.975
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 0.974
folD
5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 
 0.973
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Alternative locus ID: NATL2_19861.
 
  
 0.973
purD
Phosphoribosylamine--glycine ligase; Alternative locus ID: NATL2_17101; Belongs to the GARS family.
 
 
 0.971
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternative locus ID: NATL2_17091; Belongs to the SAICAR synthetase family.
 
 
 0.968
Your Current Organism:
Prochlorococcus marinus NATL2A
NCBI taxonomy Id: 59920
Other names: P. marinus str. NATL2A, Prochlorococcus marinus str. NATL2A, Prochlorococcus sp. NATL2A
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