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psmA psmA pan pan TSIB_1351 TSIB_1351 rrp42 rrp42 rrp4 rrp4 rrp41 rrp41 psmB2 psmB2 psmB1 psmB1 rpl15e rpl15e rpl4 rpl4 TSIB_0768 TSIB_0768
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
psmAProteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (260 aa)    
Predicted Functional Partners:
pan
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
 
 0.916
TSIB_1351
Putative RNA-associated protein.
 
    0.909
rrp42
Probable exosome complex exonuclease 2; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
 
  
 0.848
rrp4
Probable exosome complex RNA-binding protein 1; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
 
    0.846
rrp41
Probable exosome complex exonuclease 1; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
  
   0.827
psmB2
Proteasome, beta subunit 2; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.820
psmB1
Proteasome subunit beta precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.814
rpl15e
50S ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family.
 
  
 0.793
rpl4
50S ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
 
 
 
 0.763
TSIB_0768
Glycerol kinase.
   
 0.757
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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