STRINGSTRING
SMAD4 SMAD4 SMAD1 SMAD1 SMAD2 SMAD2 SMAD3 SMAD3 SMAD9 SMAD9 SMAD5 SMAD5 TGFBR2 TGFBR2 E2F4 E2F4 TGFBR1 TGFBR1 SKIL SKIL E2F5 E2F5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAD4Mothers against decapentaplegic homolog. (552 aa)    
Predicted Functional Partners:
SMAD1
Mothers against decapentaplegic homolog.
   
0.999
SMAD2
Mothers against decapentaplegic homolog.
   
0.999
SMAD3
Mothers against decapentaplegic homolog.
   
0.999
SMAD9
Mothers against decapentaplegic homolog.
   
0.998
SMAD5
Mothers against decapentaplegic homolog.
   
0.995
TGFBR2
TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]
   
 0.989
E2F4
E2F transcription factor 4.
    
 0.989
TGFBR1
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.
   
 0.989
SKIL
SKI like proto-oncogene.
   
 0.986
E2F5
E2F transcription factor 5.
    
 0.984
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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