node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cbd-1 | chs-1 | H02I12.1.1 | T25G3.2.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell. | 0.920 |
cbd-1 | cpg-1 | H02I12.1.1 | C07G2.1a.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | Chondroitin proteoglycan 1; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin. | 0.999 |
cbd-1 | cpg-2 | H02I12.1.1 | B0280.5.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | Chondroitin proteoglycan-2; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin. | 0.897 |
cbd-1 | egg-1 | H02I12.1.1 | B0244.8.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial. Redundantly with egg-2, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required together with egg-2 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane. Appears to recruit or maint [...] | 0.999 |
cbd-1 | egg-4 | H02I12.1.1 | T21E3.1.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | Inactive protein-tyrosine phosphatase egg-4; Inactive phosphatase which acts redundantly with egg-5 in the oocyte-to-zygote transition. Required for the polarization of cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-5, required for the cortical localization of kinase mbk-2 and for the inhibition of mbk-2 kinase activity in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization. | 0.887 |
cbd-1 | egg-5 | H02I12.1.1 | R12E2.10.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | Inactive protein-tyrosine phosphatase egg-5; Inactive phosphatase which acts redundantly with egg-4 in the oocyte-to-zygote transition. Required for polarized cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-4, required for the cortical localization of kinase mbk-2 in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization. | 0.999 |
cbd-1 | perm-2 | H02I12.1.1 | C44B12.1.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | PERMeable eggshell. | 0.884 |
cbd-1 | perm-4 | H02I12.1.1 | C44B12.5.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | PERMeable eggshell. | 0.887 |
cbd-1 | puf-3 | H02I12.1.1 | Y45F10A.2.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | PUM-HD domain-containing protein. | 0.999 |
cbd-1 | rme-2 | H02I12.1.1 | T11F8.3a.1 | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | Receptor Mediated Endocytosis. | 0.999 |
chs-1 | cbd-1 | T25G3.2.1 | H02I12.1.1 | Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell. | Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization. | 0.920 |
chs-1 | cpg-1 | T25G3.2.1 | C07G2.1a.1 | Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell. | Chondroitin proteoglycan 1; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin. | 0.884 |
chs-1 | cpg-2 | T25G3.2.1 | B0280.5.1 | Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell. | Chondroitin proteoglycan-2; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin. | 0.859 |
chs-1 | egg-1 | T25G3.2.1 | B0244.8.1 | Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell. | LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial. Redundantly with egg-2, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required together with egg-2 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane. Appears to recruit or maint [...] | 0.914 |
chs-1 | egg-4 | T25G3.2.1 | T21E3.1.1 | Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell. | Inactive protein-tyrosine phosphatase egg-4; Inactive phosphatase which acts redundantly with egg-5 in the oocyte-to-zygote transition. Required for the polarization of cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-5, required for the cortical localization of kinase mbk-2 and for the inhibition of mbk-2 kinase activity in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization. | 0.933 |
chs-1 | egg-5 | T25G3.2.1 | R12E2.10.1 | Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell. | Inactive protein-tyrosine phosphatase egg-5; Inactive phosphatase which acts redundantly with egg-4 in the oocyte-to-zygote transition. Required for polarized cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-4, required for the cortical localization of kinase mbk-2 in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization. | 0.880 |
chs-1 | perm-2 | T25G3.2.1 | C44B12.1.1 | Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell. | PERMeable eggshell. | 0.759 |
chs-1 | perm-4 | T25G3.2.1 | C44B12.5.1 | Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell. | PERMeable eggshell. | 0.796 |
chs-1 | puf-3 | T25G3.2.1 | Y45F10A.2.1 | Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell. | PUM-HD domain-containing protein. | 0.624 |
chs-1 | rme-2 | T25G3.2.1 | T11F8.3a.1 | Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell. | Receptor Mediated Endocytosis. | 0.892 |