node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
icd | pdhB | SLG_15400 | SLG_18970 | Isocitrate dehydrogenase (NADP+); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.572 |
icd | pdhB-2 | SLG_15400 | SLG_23990 | Isocitrate dehydrogenase (NADP+); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.572 |
icd | sdhA | SLG_15400 | SLG_11950 | Isocitrate dehydrogenase (NADP+); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.714 |
icd | sucA | SLG_15400 | SLG_00730 | Isocitrate dehydrogenase (NADP+); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 2-oxoglutarate dehydrogenase E1 component. | 0.975 |
icd | sucC | SLG_15400 | SLG_32000 | Isocitrate dehydrogenase (NADP+); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.918 |
icd | sucD | SLG_15400 | SLG_00720 | Isocitrate dehydrogenase (NADP+); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.789 |
lpd | pdhB | SLG_09680 | SLG_18970 | Protein synonym:branched-chain alpha-keto acid dehydrogenase E3 component. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
lpd | pdhB-2 | SLG_09680 | SLG_23990 | Protein synonym:branched-chain alpha-keto acid dehydrogenase E3 component. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
lpd | pdhD | SLG_09680 | SLG_00750 | Protein synonym:branched-chain alpha-keto acid dehydrogenase E3 component. | Dihydrolipoamide dehydrogenase. | 0.914 |
lpd | pdhD-2 | SLG_09680 | SLG_36250 | Protein synonym:branched-chain alpha-keto acid dehydrogenase E3 component. | Dihydrolipoamide dehydrogenase. | 0.917 |
lpd | sdhA | SLG_09680 | SLG_11950 | Protein synonym:branched-chain alpha-keto acid dehydrogenase E3 component. | Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.412 |
lpd | sucA | SLG_09680 | SLG_00730 | Protein synonym:branched-chain alpha-keto acid dehydrogenase E3 component. | 2-oxoglutarate dehydrogenase E1 component. | 0.962 |
lpd | sucB | SLG_09680 | SLG_00740 | Protein synonym:branched-chain alpha-keto acid dehydrogenase E3 component. | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.986 |
lpd | sucC | SLG_09680 | SLG_32000 | Protein synonym:branched-chain alpha-keto acid dehydrogenase E3 component. | succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.409 |
lpd | sucD | SLG_09680 | SLG_00720 | Protein synonym:branched-chain alpha-keto acid dehydrogenase E3 component. | succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.414 |
pdhB | icd | SLG_18970 | SLG_15400 | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Isocitrate dehydrogenase (NADP+); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.572 |
pdhB | lpd | SLG_18970 | SLG_09680 | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Protein synonym:branched-chain alpha-keto acid dehydrogenase E3 component. | 0.999 |
pdhB | pdhB-2 | SLG_18970 | SLG_23990 | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
pdhB | pdhD | SLG_18970 | SLG_00750 | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Dihydrolipoamide dehydrogenase. | 0.999 |
pdhB | pdhD-2 | SLG_18970 | SLG_36250 | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Dihydrolipoamide dehydrogenase. | 0.999 |