node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisE1 | hisE2 | ckrop_0918 | ckrop_0917 | phosphoribosyl-ATP pyrophosphatase. | phosphoribosyl-ATP pyrophosphatase. | 0.842 |
hisE1 | metH | ckrop_0918 | ckrop_0919 | phosphoribosyl-ATP pyrophosphatase. | 5-methyltetrahydrofolate-- homocysteinemethyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.709 |
hisE1 | mshC | ckrop_0918 | ckrop_0920 | phosphoribosyl-ATP pyrophosphatase. | MshC ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.692 |
hisE1 | uppP | ckrop_0918 | ckrop_0921 | phosphoribosyl-ATP pyrophosphatase. | Undecaprenyl pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.644 |
hisE2 | hisE1 | ckrop_0917 | ckrop_0918 | phosphoribosyl-ATP pyrophosphatase. | phosphoribosyl-ATP pyrophosphatase. | 0.842 |
hisE2 | metH | ckrop_0917 | ckrop_0919 | phosphoribosyl-ATP pyrophosphatase. | 5-methyltetrahydrofolate-- homocysteinemethyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.705 |
hisE2 | mshC | ckrop_0917 | ckrop_0920 | phosphoribosyl-ATP pyrophosphatase. | MshC ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.718 |
hisE2 | uppP | ckrop_0917 | ckrop_0921 | phosphoribosyl-ATP pyrophosphatase. | Undecaprenyl pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.644 |
mca | mshA | ckrop_0564 | ckrop_1927 | Mycothiol conjugate amidase; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. | MshA glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. | 0.818 |
mca | mshB | ckrop_0564 | ckrop_0626 | Mycothiol conjugate amidase; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. | MshB deacetylase; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway. | 0.451 |
mca | mshC | ckrop_0564 | ckrop_0920 | Mycothiol conjugate amidase; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. | MshC ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.741 |
mca | mshD | ckrop_0564 | ckrop_0397 | Mycothiol conjugate amidase; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. | MshD acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. | 0.875 |
metH | hisE1 | ckrop_0919 | ckrop_0918 | 5-methyltetrahydrofolate-- homocysteinemethyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | phosphoribosyl-ATP pyrophosphatase. | 0.709 |
metH | hisE2 | ckrop_0919 | ckrop_0917 | 5-methyltetrahydrofolate-- homocysteinemethyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | phosphoribosyl-ATP pyrophosphatase. | 0.705 |
metH | mshC | ckrop_0919 | ckrop_0920 | 5-methyltetrahydrofolate-- homocysteinemethyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | MshC ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.827 |
metH | uppP | ckrop_0919 | ckrop_0921 | 5-methyltetrahydrofolate-- homocysteinemethyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Undecaprenyl pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.759 |
mshA | mca | ckrop_1927 | ckrop_0564 | MshA glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. | Mycothiol conjugate amidase; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. | 0.818 |
mshA | mshB | ckrop_1927 | ckrop_0626 | MshA glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. | MshB deacetylase; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway. | 0.945 |
mshA | mshC | ckrop_1927 | ckrop_0920 | MshA glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. | MshC ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.875 |
mshA | mshD | ckrop_1927 | ckrop_0397 | MshA glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. | MshD acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. | 0.938 |