STRINGSTRING
Ptp4E Ptp4E CG12025 CG12025 CG32191 CG32191 Ptp69D Ptp69D Cont Cont MKP-4 MKP-4 pr pr CG13197 CG13197 exp exp Sema2b Sema2b PPP4R2r PPP4R2r
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ptp4EProtein tyrosine phosphatase 4E (Ptp4E) encodes a transmembrane receptor tyrosine phosphatase closely related to the product of Ptp10D. Ptp4E single mutants have no known phenotypes. However, Ptp4E-Ptp10D double mutants have lethal respiratory defects. The product of Ptp4E regulates signaling through the receptor tyrosine kinases encoded by Egfr, btl and Pvr. (1767 aa)    
Predicted Functional Partners:
CG12025
RH22148p.
      
 0.732
CG32191
MIP05773p; Sulfuric ester hydrolase activity.
      
 0.630
Ptp69D
Protein tyrosine phosphatase 69D (Ptp69D) encodes a transmembrane receptor tyrosine phosphatase (RPTP). It genetically interacts with the other RPTP genes and its mutants have embryonic motor axon guidance phenotypes. In particular, Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. The product of Ptp69D physically and genetically interacts with the product of Dscam1 to regulate arborization of mechanosensory neurons; Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.
  
 
0.559
Cont
Contactin; Required for organization of septate junctions and paracellular barrier functions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion.
  
 
 
 0.529
MKP-4
Dual specificity protein phosphatase MPK-4; Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. May suppress bsk/JNK activation during the immune response.
   
 
 0.519
pr
6-pyruvoyl tetrahydrobiopterin synthase; Required for pigment and biopterin synthesis. Belongs to the PTPS family.
      
 0.506
CG13197
RE27552p; Protein tyrosine/serine/threonine phosphatase activity; polynucleotide 5'-phosphatase activity; protein tyrosine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation.
      
 0.493
exp
Expansion, isoform A; Expansion (exp) encodes an atypical Smad-like protein which regulates tube size in the trachea through receptor tyrosine kinase (RTK) pathways, as well as apical secretion pathways.
  
   
 0.488
Sema2b
Semaphorin 2b (Sema2b) encodes a member of the Semaphorins family, which are membrane and secreted short-range signaling proteins. The product of Sema2b contributes to the regulation of axon and dendrite guidance as well as cell-matrix adhesion.
  
 
 
 0.485
PPP4R2r
Serine/threonine-protein phosphatase 4 regulatory subunit 2; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) (By similarity). The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro).
   
  
 0.466
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.