STRINGSTRING
Setd3 Setd3 Rab40 Rab40 Nbr Nbr Smyd3 Smyd3 CG3071 CG3071 CG33172 CG33172 lost lost CG31342 CG31342 TyrRS TyrRS sol sol CG9286 CG9286
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
Setd3Actin-histidine N-methyltransferase; Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-74'. Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family. (537 aa)    
Predicted Functional Partners:
Rab40
Rab40, isoform B; GTP binding; GTPase activity. It is involved in the biological process described with: protein localization to plasma membrane; vesicle-mediated transport; Rab protein signal transduction; intracellular protein transport.
   
    0.828
Nbr
Exonuclease mut-7 homolog; Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs, in particular multiple-isoform miRNAs, which represents a critical step in miRNA maturation. Belongs to the mut-7 family.
   
    0.797
Smyd3
SET and MYND domain containing, class 3; Histone-lysine N-methyltransferase activity; protein-lysine N-methyltransferase activity. It is involved in the biological process described with: histone lysine methylation.
   
  
 0.717
CG3071
LD43561p; snoRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA processing; positive regulation of transcription by RNA polymerase I.
   
    0.706
CG33172
MIP10235p; RNA binding. It is involved in the biological process described with: negative regulation of cell population proliferation.
   
    0.693
lost
LD30155p; Lost (lost) encodes a protein that interacts with the RNA-binding protein encoded by rump for posterior localization of mRNAs by diffusion/entrapment during late stages of oogenesis. The identification of the product of lost in various RNP complexes suggests a broad role in RNA metabolism.
   
    0.687
CG31342
FI13065p.
   
    0.681
TyrRS
tRNA binding; tyrosine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: tyrosyl-tRNA aminoacylation.
   
 
 0.672
sol
Calpain-D; Has a role in eye development; Belongs to the peptidase C2 family.
   
    0.672
CG9286
Protein BCCIP homolog; Protein kinase regulator activity; tubulin binding; kinase regulator activity; Belongs to the BCP1 family.
   
 
 0.667
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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