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Gad1 Gad1 GLS GLS VGAT VGAT Gabat Gabat Gdh Gdh CG5493 CG5493 P5CDh1 P5CDh1 Aldh-III Aldh-III Gs2 Gs2 VGlut VGlut CG9674 CG9674
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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Gad1Glutamic acid decarboxylase 1 (Gad1) encodes an essential, nervous system-specific glutamic acid decarboxylase, which is the synthetic enzyme for the major inhibitory neurotransmitter gamma-Aminobutyric acid (GABA). It is required for a multitude of physiological functions and adult behaviors dependent on GABA, including sleep, memory, circadian rhythms and egg hatching; Belongs to the group II decarboxylase family. (510 aa)    
Predicted Functional Partners:
GLS
Glutaminase, isoform H; Glutaminase activity. It is involved in the biological process described with: glutamine catabolic process; glutamine metabolic process; glutamate biosynthetic process.
  
 
 0.953
VGAT
Vesicular GABA Transporter (VGAT) encodes an essential transporter that is responsible for packaging the neurotransmitter GABA into synaptic vesicles.
   
 
 0.946
Gabat
Gamma-aminobutyric acid transaminase (Gabat) encodes an enzyme involved in the breakdown of the sleep-promoting neurotransmitter gamma-aminobutyric (GABA). It functions in mitochondria, in a shunt of the TCA cycle, and is implicated in the regulation of sleep as well as in metabolism; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.941
Gdh
Glutamate dehydrogenase, mitochondrial; Glutamate dehydrogenase (Gdh) encodes a glutamate dehydrogenase involved glutamate metabolism.
   
 
 0.936
CG5493
Cysteine dioxygenase activity; ferrous iron binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. It is involved in the biological process described with: oxidation-reduction process; L-cysteine catabolic process.
     
 0.927
P5CDh1
delta-1-Pyrroline-5-carboxylate dehydrogenase 1 (P5CDh1) encodes a conserved, nuclear-encoded mitochondrial matrix enzyme. It is a member of the aldehyde dehydrogenase superfamily involved in proline degradation.
   
 0.925
Aldh-III
Aldehyde dehydrogenase type III (Aldh-III) encodes a protein that confers a xenobiotic stress resistance by oxidising aromatic aldehydes (benzaldehyde). It also neutralises the lipid aldehydes formed after the attack of reactive oxygen and radicals, such as malondialdehyde during lipid peroxidation. The catalytic redox reaction uses NAD(P)+ as a cofactor.
   
 0.924
Gs2
Glutamine synthetase 2 (Gs2) encodes an enzyme that converts glutamate to glutamine. It is expressed in the embryonic nervous system and regulates the size of glutamate neurotransmitter pools and synapse assembly.
  
 
 0.923
VGlut
Vesicular glutamate transporter, isoform A.
   
 
 0.920
CG9674
Uncharacterized protein, isoform F; It is involved in the biological process described with: glutamate biosynthetic process; ammonia assimilation cycle; oxidation-reduction process.
   
 
 0.914
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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