STRINGSTRING
l(1)G0007 l(1)G0007 Slu7 Slu7 CG6015 CG6015 Cwc25 Cwc25 Prp18 Prp18 ncm ncm l(2)37Cb l(2)37Cb CG10324 CG10324 CG12343 CG12343 CG4849 CG4849 Cdc5 Cdc5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
l(1)G0007Lethal (1) G0007 (l(1)G0007) encodes a protein involved in alternative mRNA splicing regulation. (1222 aa)    
Predicted Functional Partners:
Slu7
Pre-mRNA-splicing factor Slu7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
   
 0.998
CG6015
LD21931p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 0.996
Cwc25
LD47748p; It is involved in the biological process described with: mRNA splicing, via spliceosome.
    
 
 0.988
Prp18
Putative mRNA splicing factor; It is involved in the biological process described with: generation of catalytic spliceosome for second transesterification step; mRNA splicing, via spliceosome; nuclear retention of unspliced pre-mRNA at the site of transcription.
    
 
 0.986
ncm
Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders eIF4AIII from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs.
   
 0.984
l(2)37Cb
Lethal (2) 37Cb; RNA binding; RNA helicase activity. It is involved in the biological process described with: mRNA splicing, via spliceosome.
  
0.973
CG10324
FI23980p1.
   
 0.971
CG12343
Pre-mRNA-splicing factor Syf2; Involved in pre-mRNA splicing as component of the spliceosome.
    
 
 0.961
CG4849
LD28793p; U5 snRNA binding; GTP binding; GTPase activity; translation elongation factor activity. It is involved in the biological process described with: mRNA splicing, via spliceosome; translational elongation; positive regulation of gene expression.
   
 
 0.959
Cdc5
Cell division cycle 5, isoform A; DNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
 
 
 
 0.957
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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