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eIF2alpha eIF2alpha eIF2Bbeta eIF2Bbeta eIF2Bdelta eIF2Bdelta eIF2beta eIF2beta PEK PEK Rpn11 Rpn11 eIF2Balpha eIF2Balpha eIF2Bgamma eIF2Bgamma eIF5 eIF5 eIF2Bepsilon eIF2Bepsilon Gcn2 Gcn2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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Predicted Interactions
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textmining
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protein homology
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eIF2alphaEukaryotic translation initiation factor 2 subunit alpha (eIF2alpha) encodes one of three subunits of the eIF-2 complex required for the initiation of translation. eIF2alpha is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles. (341 aa)    
Predicted Functional Partners:
eIF2Bbeta
Eukaryotic translation initiation factor 2B subunit beta; Translation initiation factor activity; guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: cellular response to hypoxia; regulation of translational initiation; translational initiation; Belongs to the eIF-2B alpha/beta/delta subunits family.
   
 0.999
eIF2Bdelta
Eukaryotic translation initiation factor 2B subunit delta, isoform A; Translation initiation factor activity. It is involved in the biological process described with: translational initiation; Belongs to the eIF-2B alpha/beta/delta subunits family.
   
 0.999
eIF2beta
Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region; Belongs to the eIF-2-beta/eIF-5 family.
   
 0.999
PEK
Eukaryotic translation initiation factor 2-alpha kinase; Pancreatic eIF-2alpha kinase (PEK) encodes an endoplasmic reticulum (ER) transmembrane kinase and a component of the integrated stress response. During ER stress the product of PEK phosphorylates the translation initiation factor encoded by eIF2alpha resulting in the inhibition of most cap-dependent translation. This is especially important during the development of secretory tissues and the response to cellular stress; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
   
 0.999
Rpn11
26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). Belongs to the peptidase M67A family. PSMD14 subfamily.
   
 
 0.999
eIF2Balpha
Eukaryotic translation initiation factor 2B subunit alpha (eIF2Balpha) encodes a regulatory subunit of the eIF2B heteropentamer; Belongs to the eIF-2B alpha/beta/delta subunits family.
   
 0.999
eIF2Bgamma
Eukaryotic translation initiation factor 2B subunit gamma; Translation initiation factor activity; nucleotidyltransferase activity; guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: translational initiation; cellular response to hypoxia; cytoplasmic translational initiation.
   
 0.999
eIF5
Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity).
   
 0.999
eIF2Bepsilon
Eukaryotic translation initiation factor 2B subunit epsilon (eIF2Bepsilon) encodes a guanyl-nucleotide exchange factor.
   
 0.999
Gcn2
Gcn2, isoform C; Gcn2 (Gcn2) encodes a kinase activated during amino acid starvation to phosphorylate the eIF2 subunit encoded by eIF2alpha. Gcn2 product plays roles in ageing, dpp signalling, dietary choice and response to infection.
   
 0.999
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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