STRINGSTRING
ERR ERR Cka Cka tai tai p23 p23 Fkbp59 Fkbp59 Egfr Egfr Hr96 Hr96 Smr Smr CG8314 CG8314 Ccs Ccs Art1 Art1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
ERREstrogen-related receptor (ERR) encodes a protein that directly induces a transcriptional switch in mid-embryogenesis, up-regulating the genes that act in biosynthetic pathways associated with aerobic glycolysis. This nuclear receptor establishes the metabolic state that supports growth during larval stages. (496 aa)    
Predicted Functional Partners:
Cka
Connector of kinase to AP-1, isoform E; Protein binding.
    
  0.900
tai
Taiman, isoform G; Taiman (tai) encodes an ecdysone receptor co-activator related to mammalian steroid receptor coactivator (SRC) proteins. It contributes to border cell migration.
    
 0.869
p23
Uncharacterized protein CG16817; prostaglandin-E synthase activity; Hsp90 protein binding; chaperone binding. It is involved in the biological process described with: protein folding; positive regulation of small RNA loading onto RISC; chaperone-mediated protein complex assembly; Belongs to the p23/wos2 family.
   
  0.821
Fkbp59
FK506-binding protein 59kD (Fkbp59) encodes a peptidylprolyl isomerase involved in the regulation of calcium transport and phototransduction.
   
 0.814
Egfr
Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...]
    
 0.780
Hr96
Hormone receptor-like in 96 (Hr96) encodes a protein that binds cholesterol as a ligand and is required to maintain cholesterol and lipid homeostasis; Belongs to the nuclear hormone receptor family. NR1 subfamily.
  
 
0.772
Smr
Smrter, isoform G; It is involved in the biological process described with: wing disc development; regulation of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; ovarian follicle cell development.
    
 0.765
CG8314
Protein-cysteine S-palmitoyltransferase activity. It is involved in the biological process described with: peptidyl-L-cysteine S-palmitoylation; protein palmitoylation; protein targeting to membrane.
   
 
  0.755
Ccs
Copper chaperone for superoxide dismutase (Ccs) encodes a protein required for the proper superoxide dismutase function of the product of Sod1. It is involved in determination of lifespan, oxidative stress, and cytosolic aconitase activity.
   
    0.709
Art1
Protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; histone methyltransferase activity (H4-R3 specific); histone methyltransferase activity. It is involved in the biological process described with: histone methylation; histone H4-R3 methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
    
 0.704
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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