STRINGSTRING
Rint1 Rint1 Zw10 Zw10 Syx18 Syx18 Use1 Use1 Sec22 Sec22 Rab18 Rab18 Cog3 Cog3 Zwilch Zwilch CG7156 CG7156 S6kII S6kII JIL-1 JIL-1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Rint1RINT1-like protein; During cytokinesis in male meiotic cells, required for completion of cleavage furrow ingression possibly in conjunction with Zw10. Required for maintenance of Golgi stack number and morphology. Essential for acroblast assembly. (724 aa)    
Predicted Functional Partners:
Zw10
Centromere/kinetochore protein zw10; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores. During cytokinesis in male meiotic cells it is required for completion of cleavage furrow ingression, possibly in conjunction with Rint1. Required for maintenance of Golgi stack number and morphology, and acroblast assembly. Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex. Failure [...]
  
 0.999
Syx18
Syntaxin 18 (Syx18) encodes a SNAP receptor involved in neuromuscular synaptic transmission.
   
 0.996
Use1
Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi- derived retrograde transport vesicles with the ER (By similarity). Required for protein secretion.
   
 0.977
Sec22
Secretory 22, isoform B; Secretory 22 (Sec22) encodes a protein involved in Wnt protein secretion; Belongs to the synaptobrevin family.
   
 0.973
Rab18
GH11193p; Protein binding; GTPase activity; GTP binding. It is involved in the biological process described with: vesicle-mediated transport; Rab protein signal transduction; intracellular protein transport; lipid droplet organization.
    
 
 0.967
Cog3
Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport.
   
  
 0.886
Zwilch
Protein zwilch; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex. Failure to assemble the complex due to the absence of any one of its components, results in the incorrect redistribution of the remaining components to diverse membrane compartments ; Belongs to the ZWILCH family.
      
 0.883
CG7156
LD24550p; Protein serine/threonine kinase activity; phosphatidylinositol binding; ATP binding. It is involved in the biological process described with: protein phosphorylation.
   
 
 0.865
S6kII
Ribosomal protein S6 kinase II (S6kII) encodes a protein that functions as a downstream effector and regulator of the MAP kinase pathway. It is involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning.
   
 
 0.858
JIL-1
Chromosomal serine/threonine-protein kinase JIL-1; Phosphorylates 'Ser-10' of histone H3. May regulate gene expression by establishing or maintaining the structure of more open chromatin regions. Also required for normal polytene chromosome structure, for oogenesis and for viability throughout development. Regulates the structure of polytene chromosomes in salivary glands. May phosphorylate 'Ser-1' of histone H2A.
    
 
 0.853
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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