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Pcp Pcp Lcp65Ag3 Lcp65Ag3 Edg84A Edg84A Bap60 Bap60 polybromo polybromo Snr1 Snr1 mor mor RpS17 RpS17 Bap111 Bap111 CG42500 CG42500 CG32071 CG32071
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
PcpPupal cuticle protein; Component of the cuticle of the pupa of fruit fly. (184 aa)    
Predicted Functional Partners:
Lcp65Ag3
Larval cuticle protein; Structural constituent of cuticle; structural constituent of chitin-based larval cuticle. It is involved in the biological process described with: chitin-based cuticle development.
      
 0.628
Edg84A
Pupal cuticle protein Edg-84A; Ecdysone-dependent gene 84A (Edg84A) encodes a pupal cuticle protein, assumed to be component of the exocuticle. Edg84A is expressed only in anterior epidermis during the late prepupal period, induced by the transcription factor encoded by ftz-f1.
   
 
 0.606
Bap60
Brahma-associated protein of 60 kDa; Involved in the recruitment and site-specific anchoring of the Brahma complex at specific promoter sites. The Brahma complex is a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. Participates in X-chromosomal dosage compensation. Participates in neurogenesis.
   
 
 0.587
polybromo
Polybromo (polybromo) encodes a subunit of Polybromo-associated Brahma complex (PBAP). Its main biological role is involved in chromatin remodeling together with Brahma complex. It can also regulate gene transcription through DNA binding, which is dependent or independent ofthe PBAP complex.
   
 
 0.587
Snr1
Snf5-related 1 (Snr1) encodes a core component of the ATP-dependent SWI/SNF chromatin-remodeling complex (Brahma complex). It functions as a tumor suppressor and is required for maintaining normal endosomal trafficking-mediated signaling cascades; Belongs to the SNF5 family.
   
 
 0.584
mor
Brahma associated protein 155 kDa; Moira (mor) encodes a member of the trithorax group of homeotic gene regulators. The product of mor is a chromatin remodeling protein and functions as the Swi3 component of the Brahma complex.
   
 
 0.584
RpS17
Ribosomal protein S17 (RpS17) encodes an essential component of the ribosomal 40S subunit. RpS17 mutants have dominant, haploinsufficient effects on cellular and organismal growth rate, and on bristle size; Belongs to the eukaryotic ribosomal protein eS17 family.
    
 
 0.579
Bap111
Brahma associated protein 111kD (Bap111) encodes a protein important for Brahma complex function. It is involved in chromatin remodeling and transcription induction.
   
 
 0.559
CG42500
Uncharacterized protein, isoform A.
   
  
 0.557
CG32071
Uncharacterized protein.
   
  
 0.532
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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