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ninaG ninaG ninaB ninaB pinta pinta ninaD ninaD santa-maria santa-maria ninaA ninaA ninaE ninaE CG34138 CG34138 Rh4 Rh4 IFT52 IFT52 Cpn Cpn
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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textmining
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protein homology
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ninaGNeither inactivation nor afterpotential protein G; Oxidoreductase involved in biosynthesis of 3-hydroxyretinal, a chromophore for rhodopsin Rh1. Not responsible for the initial hydroxylation of the retinal ring but rather acts in a subsequent step in chromophore production. May catalyze the conversion of (3R)-3- hydroxyretinol to the 3S enantiomer. (597 aa)    
Predicted Functional Partners:
ninaB
Carotenoid isomerooxygenase; Catalyzes the oxidative cleavage at the 15,15'-double bond of carotenoids and the simultaneous all-trans to 11-cis isomerization of one cleavage product. Carotenoids like 11-cis retinal can promote visual pigment biogenesis in the dark. Essential for the biosynthesis of the 3-hydroxyretinal chromophore of rhodopsin from zeaxanthin and for proper photoreceptor development. Also essential for larval light perception.
   
  
 0.866
pinta
Retinol-binding protein pinta; Retinoid-binding protein which shows highest affinity for all-trans retinol. Can also bind all-trans forms of retinoic acid and retinal, but has lower affinity for cis form retinoids. Required in retinal pigment cells for rhodopsin biosynthesis.
   
  
 0.837
ninaD
Neither inactivation nor afterpotential D (ninaD) encodes a scavenger receptor involved in carotenoid transport, light detection and rhodopsin biosynthesis; Belongs to the CD36 family.
      
 0.835
santa-maria
Scavenger receptor acting in neural tissue and majority of rhodopsin is absent (santa-maria) encodes a class B scavenger receptor that contributes to the conversion of carotenoids to vitamin A. It is involved in phototransduction and thermotaxis; Belongs to the CD36 family.
      
 0.790
ninaA
Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction. Belongs to the cyclophilin-type PPIase family.
   
  
 0.726
ninaE
Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization.
   
  
 0.644
CG34138
IP17336p.
      
 0.620
Rh4
Opsin Rh4; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
   
  
 0.578
IFT52
Intraflagellar transport 52.
    
 
 0.554
Cpn
Calphotin (Cpn) encodes a glutamic acid-rich protein with a strong negative charge and a highly hydrophobic amino acid composition. It functions as an immobile Ca[2+] buffer along the base of the photoreceptor's microvilli. It protects the photoreceptor cells from Ca[2+] overload and light induced degeneration.
   
  
 0.521
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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