node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG10086 | Sap-r | FBpp0081241 | FBpp0085075 | RE33762p; It is involved in the biological process described with: protein transport. | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | 0.662 |
CG8460 | Sap-r | FBpp0079207 | FBpp0085075 | LD18607p; Oligosaccharide binding; chitin binding. It is involved in the biological process described with: carbohydrate metabolic process; Belongs to the glycosyl hydrolase 18 family. | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | 0.750 |
Chc | Lamp1 | FBpp0089398 | FBpp0085251 | Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. | FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. | 0.619 |
Chc | Sap-r | FBpp0089398 | FBpp0085075 | Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | 0.788 |
Cp1 | Lamp1 | FBpp0086719 | FBpp0085251 | Cathepsin L heavy chain; Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion; Belongs to the peptidase C1 family. | FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. | 0.631 |
Cp1 | Sap-r | FBpp0086719 | FBpp0085075 | Cathepsin L heavy chain; Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion; Belongs to the peptidase C1 family. | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | 0.750 |
Cp1 | cathD | FBpp0086719 | FBpp0402840 | Cathepsin L heavy chain; Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion; Belongs to the peptidase C1 family. | CathD, isoform A; cathD (cathD) encodes a protein involved in apoptosis and the defense response to Gram-negative bacteria; Belongs to the peptidase A1 family. | 0.971 |
Gba1b | Sap-r | FBpp0306807 | FBpp0085075 | Glucosylceramidase; Glucocerebrosidase 1b (Gba1b) encodes a lysosomal acid beta glucocerebrosidase that catalyzes the hydrolysis of glucosylceramide to ceramide and glucose. | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | 0.924 |
Lamp1 | Chc | FBpp0085251 | FBpp0089398 | FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. | Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. | 0.619 |
Lamp1 | Cp1 | FBpp0085251 | FBpp0086719 | FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. | Cathepsin L heavy chain; Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion; Belongs to the peptidase C1 family. | 0.631 |
Lamp1 | Sap-r | FBpp0085251 | FBpp0085075 | FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | 0.739 |
Lamp1 | cathD | FBpp0085251 | FBpp0402840 | FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. | CathD, isoform A; cathD (cathD) encodes a protein involved in apoptosis and the defense response to Gram-negative bacteria; Belongs to the peptidase A1 family. | 0.931 |
Manf | Sap-r | FBpp0082735 | FBpp0085075 | Mesencephalic astrocyte-derived neurotrophic factor (Manf) encodes an evolutionarily conserved neurotrophic factor. It contributes to dopamine neuron survival, regulation of unfolded protein response and retinal repair. | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | 0.901 |
Manf | sel | FBpp0082735 | FBpp0087519 | Mesencephalic astrocyte-derived neurotrophic factor (Manf) encodes an evolutionarily conserved neurotrophic factor. It contributes to dopamine neuron survival, regulation of unfolded protein response and retinal repair. | Protein seele; Involved in embryonic dorsal-ventral patterning which is generated by a series of serine protease processing events where gd processes snk which cleaves ea which then processes spz into the activating ligand for the Toll receptor. Required during this process for the secretion of ea from the developing embryo into the perivitelline space and for ea processing. Belongs to the canopy family. | 0.499 |
Prosbeta4R1 | Sap-r | FBpp0077381 | FBpp0085075 | Proteasome subunit beta; Threonine-type endopeptidase activity; endopeptidase activity. It is involved in the biological process described with: proteasomal ubiquitin-independent protein catabolic process; proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process. | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | 0.669 |
Sap-r | CG10086 | FBpp0085075 | FBpp0081241 | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | RE33762p; It is involved in the biological process described with: protein transport. | 0.662 |
Sap-r | CG8460 | FBpp0085075 | FBpp0079207 | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | LD18607p; Oligosaccharide binding; chitin binding. It is involved in the biological process described with: carbohydrate metabolic process; Belongs to the glycosyl hydrolase 18 family. | 0.750 |
Sap-r | Chc | FBpp0085075 | FBpp0089398 | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. | 0.788 |
Sap-r | Cp1 | FBpp0085075 | FBpp0086719 | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | Cathepsin L heavy chain; Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion; Belongs to the peptidase C1 family. | 0.750 |
Sap-r | Gba1b | FBpp0085075 | FBpp0306807 | Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. | Glucosylceramidase; Glucocerebrosidase 1b (Gba1b) encodes a lysosomal acid beta glucocerebrosidase that catalyzes the hydrolysis of glucosylceramide to ceramide and glucose. | 0.924 |