STRINGSTRING
Ca-alpha1T Ca-alpha1T para para NaCP60E NaCP60E Ca-alpha1D Ca-alpha1D cac cac Ca-beta Ca-beta CG4587 CG4587 stj stj na na CG16868 CG16868 RyR RyR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ca-alpha1TCa[2+]-channel protein alpha[[1]] subunit T (Ca-alpha1T) encodes an alpha 1 subunit of a T-type like voltage gated calcium channel. It mediates a low voltage activated transient calcium current in antennal lobe projection neurons and wing motoneurons that is sensitive to amiloride. (3218 aa)    
Predicted Functional Partners:
para
Sodium channel protein para; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily.
   
0.853
NaCP60E
Na channel protein 60E (NaCP60E) encodes a voltage-gated calcium-selective cation channel that likely modulates the stability of neural circuits, particularly under environmental stresses; Belongs to the sodium channel (TC 1.A.1.10) family. NaCP60E subfamily.
   
0.834
Ca-alpha1D
Voltage-dependent calcium channel type D subunit alpha-1; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Encodes a dihydropyridine- and diltiazem- sensitive current in larval body wall muscle. Vital for embryonic development; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
   
0.829
cac
Voltage-dependent calcium channel type A subunit alpha-1; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (By similarity). Probably encodes a dihydropyridine- insensitive current. Vital for survival to adulthood.
   
0.812
Ca-beta
Ca2+-channel-protein-beta-subunit, isoform L; Voltage-gated calcium channel activity; high voltage-gated calcium channel activity.
   
  
 0.756
CG4587
Uncharacterized protein, isoform H; Voltage-gated calcium channel activity.
   
 
 0.744
stj
Straightjacket, isoform C; Straightjacket (stj) encodes a voltage-gated calcium channel subunit involved in neuromuscular junction development and autophagosome maturation.
   
 
 0.740
na
Narrow abdomen, isoform F; Narrow abdomen (na) encodes an ion channel involved in circadian locomotor rhythms and touch perception.
   
 
0.672
CG16868
VWFA and cache domain-containing protein CG16868; Voltage-gated calcium channel activity.
   
 
 0.664
RyR
Ryanodine receptor (RyR) encodes an intracellular calcium channel localized in the sarcoplasmic reticulum of muscles and the endoplasmic reticulum of neurons and other cell types. It regulates the release of intracellular calcium stores and has a key role in muscle contraction.
   
  
 0.655
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.