STRINGSTRING
Dbp80 Dbp80 Gle1 Gle1 Nup214 Nup214 RpL15 RpL15 nop5 nop5 CG4364 CG4364 CG5033 CG5033 CG9143 CG9143 CG8611 CG8611 Non1 Non1 Rs1 Rs1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
Dbp80DEAD-box helicase Dbp80; Dead box protein 80 (Dbp80) encodes a putative ATP-dependent RNA helicase (DEAD box helicase), based on sequence similarity to other Dead box proteins, which are involved in mRNA export from the nucleus. (481 aa)    
Predicted Functional Partners:
Gle1
Nucleoporin Gle1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity).
    
 0.933
Nup214
Nuclear pore complex protein Nup214; Serves as a docking site in the receptor-mediated import of substrates across the nuclear pore complex including emb, RanGAP and phosphorylated Mad. Protects mbo/Nup88 from proteasomal degradation at the nuclear pore. Together with mbo/Nup88, sequesters emb in the cytoplasm and thereby attenuates nuclear export signal (NES)-mediated nuclear export. Together with mbo/Nup88, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response.
    
 
 0.892
RpL15
60S ribosomal protein L15; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL15 family.
   
 
 0.874
nop5
CG10206-PA; snoRNA binding. It is involved in the biological process described with: rRNA processing.
  
 
 0.723
CG4364
Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family.
   
 
 0.722
CG5033
Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family.
   
 
 0.679
CG9143
LD11580p; ATP binding; RNA binding; RNA helicase activity.
  
 
0.649
CG8611
Probable ATP-dependent RNA helicase CG8611; Probable ATP-dependent RNA helicase.
  
 
0.640
Non1
Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Required for normal assembly of the mitotic spindle. May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
   
 
 0.639
Rs1
Rs1, isoform A; ATP binding; RNA helicase activity; RNA binding; Belongs to the DEAD box helicase family.
  
 
0.636
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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