STRINGSTRING
HUGA_APIME HUGA_APIME MELT MELT Apamin Apamin Pla2 Pla2 LOC413462 LOC413462 LOC409814 LOC409814 A0A087ZZX8 A0A087ZZX8 LOC412829 LOC412829 A0A087ZZX7 A0A087ZZX7 LOC552073 LOC552073 LOC410884 LOC410884
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
HUGA_APIMEHyaluronidase; Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides. (382 aa)    
Predicted Functional Partners:
MELT
Melittin; Melittin: Main toxin of bee venom with strong hemolytic activity and antimicrobial activity. It has enhancing effects on bee venom phospholipase A2 activity. This amphipathic toxin binds to negatively charged membrane surface and forms pore by inserting into lipid bilayers inducing the leakage of ions and molecules and the enhancement of permeability that ultimately leads to cell lysis. It acts as a voltage-gated pore with higher selectivity for anions over cations. The ion conductance has been shown to be voltage- dependent. Self-association of melittin in membranes is promo [...]
      
 0.994
Apamin
Apamin; Neurotoxin that blocks voltage-independent calcium-activated potassium channels (KCa2.1/KCNN1/SK1, KCa2.2/KCNN2/SK2, KCa2.3/KCNN3/SK3).
      
 0.990
Pla2
Phospholipase A2; PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides; Belongs to the phospholipase A2 family. Group III subfamily.
      
 0.946
LOC413462
Uncharacterized protein.
    
 0.938
LOC409814
Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.
     
 0.921
A0A087ZZX8
Sulfatase domain-containing protein.
   
 
 0.909
LOC412829
Sulfatase domain-containing protein.
     
 0.904
A0A087ZZX7
Sulfatase domain-containing protein.
     
 0.904
LOC552073
Sulfatase domain-containing protein.
     
 0.904
LOC410884
Lipase domain-containing protein.
    
 0.867
Your Current Organism:
Apis mellifera
NCBI taxonomy Id: 7460
Other names: A. mellifera, Apis mellifica, European honey bee, Western honey bee, bee, honey bee, honeybee
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