node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEC01279.1 | AEC01308.1 | Spico_0037 | Spico_0066 | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase; Belongs to the thymidine kinase family. | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.908 |
AEC01279.1 | AEC01688.1 | Spico_0037 | Spico_0460 | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase; Belongs to the thymidine kinase family. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. | 0.913 |
AEC01279.1 | AEC02188.1 | Spico_0037 | Spico_0964 | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase; Belongs to the thymidine kinase family. | COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334; KEGG: ppy:PPE_01086 5'-nucleotidase/2',3'-cyclic phosphodiesterase; PFAM: 5'-Nucleotidase, C-terminal; Metallo-dependent phosphatase; PRIAM: 5'-nucleotidase; SPTR: 5'-nucleotidase/2',3'-cyclic phosphodiesterase; IMG reference gene:2503957269; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain. | 0.903 |
AEC01279.1 | AEC02329.1 | Spico_0037 | Spico_1108 | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase; Belongs to the thymidine kinase family. | COGs: COG0813 Purine-nucleoside phosphorylase; InterPro IPR000845; KEGG: csh:Closa_1682 purine nucleoside phosphorylase; PFAM: Nucleoside phosphorylase domain; PRIAM: Purine-nucleoside phosphorylase; SPTR: Purine nucleoside phosphorylase deoD-type; IMG reference gene:2503957416; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD). | 0.923 |
AEC01279.1 | AEC02519.1 | Spico_0037 | Spico_1311 | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase; Belongs to the thymidine kinase family. | dCMP deaminase; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125; KEGG: clo:HMPREF0868_0032 cytidine and deoxycytidylate deaminase zinc-binding region; PFAM: CMP/dCMP deaminase, zinc-binding; PRIAM: dCMP deaminase; SPTR: dCMP deaminase; IMG reference gene:2503957622; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | 0.927 |
AEC01279.1 | deoC | Spico_0037 | Spico_0036 | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase; Belongs to the thymidine kinase family. | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | 0.828 |
AEC01279.1 | dut | Spico_0037 | Spico_0600 | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase; Belongs to the thymidine kinase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.965 |
AEC01279.1 | surE | Spico_0037 | Spico_1231 | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase; Belongs to the thymidine kinase family. | Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
AEC01279.1 | thyX | Spico_0037 | Spico_1594 | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase; Belongs to the thymidine kinase family. | Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.917 |
AEC01279.1 | tmk | Spico_0037 | Spico_0587 | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase; Belongs to the thymidine kinase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.934 |
AEC01308.1 | AEC01279.1 | Spico_0066 | Spico_0037 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase; Belongs to the thymidine kinase family. | 0.908 |
AEC01308.1 | AEC01688.1 | Spico_0066 | Spico_0460 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. | 0.924 |
AEC01308.1 | AEC02188.1 | Spico_0066 | Spico_0964 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334; KEGG: ppy:PPE_01086 5'-nucleotidase/2',3'-cyclic phosphodiesterase; PFAM: 5'-Nucleotidase, C-terminal; Metallo-dependent phosphatase; PRIAM: 5'-nucleotidase; SPTR: 5'-nucleotidase/2',3'-cyclic phosphodiesterase; IMG reference gene:2503957269; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain. | 0.914 |
AEC01308.1 | AEC02329.1 | Spico_0066 | Spico_1108 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | COGs: COG0813 Purine-nucleoside phosphorylase; InterPro IPR000845; KEGG: csh:Closa_1682 purine nucleoside phosphorylase; PFAM: Nucleoside phosphorylase domain; PRIAM: Purine-nucleoside phosphorylase; SPTR: Purine nucleoside phosphorylase deoD-type; IMG reference gene:2503957416; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD). | 0.926 |
AEC01308.1 | surE | Spico_0066 | Spico_1231 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.902 |
AEC01688.1 | AEC01279.1 | Spico_0460 | Spico_0037 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. | COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: ssm:Spirs_0100 thymidine kinase; PFAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2503956301; PFAM: Thymidine kinase; Belongs to the thymidine kinase family. | 0.913 |
AEC01688.1 | AEC01308.1 | Spico_0460 | Spico_0066 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.924 |
AEC01688.1 | AEC02188.1 | Spico_0460 | Spico_0964 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. | COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334; KEGG: ppy:PPE_01086 5'-nucleotidase/2',3'-cyclic phosphodiesterase; PFAM: 5'-Nucleotidase, C-terminal; Metallo-dependent phosphatase; PRIAM: 5'-nucleotidase; SPTR: 5'-nucleotidase/2',3'-cyclic phosphodiesterase; IMG reference gene:2503957269; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain. | 0.902 |
AEC01688.1 | AEC02329.1 | Spico_0460 | Spico_1108 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. | COGs: COG0813 Purine-nucleoside phosphorylase; InterPro IPR000845; KEGG: csh:Closa_1682 purine nucleoside phosphorylase; PFAM: Nucleoside phosphorylase domain; PRIAM: Purine-nucleoside phosphorylase; SPTR: Purine nucleoside phosphorylase deoD-type; IMG reference gene:2503957416; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD). | 0.931 |
AEC01688.1 | deoC | Spico_0460 | Spico_0036 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | 0.415 |