node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HELO_3283 | HELO_3707 | HELO_3283 | HELO_3707 | TRAP transporter (tripartite ATP-independent periplasmic transporter), small transmembrane protein (DctQ component), substrate unknown. | TRAP transporter small transmembrane protein (tripartite ATP-independent periplasmic transporter; DctQ component). | 0.518 |
HELO_3283 | teaA | HELO_3283 | HELO_4274 | TRAP transporter (tripartite ATP-independent periplasmic transporter), small transmembrane protein (DctQ component), substrate unknown. | TRAP transporter substrate-binding protein TeaA (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Binds ectoine with high affinity. Affinity for hydroxyectoine is approximately 20-fold lower. | 0.481 |
HELO_3283 | teaC | HELO_3283 | HELO_4276 | TRAP transporter (tripartite ATP-independent periplasmic transporter), small transmembrane protein (DctQ component), substrate unknown. | TRAP transporter large transmembrane protein TeaC (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Belongs to the TRAP transporter large permease family. | 0.539 |
HELO_3707 | HELO_3283 | HELO_3707 | HELO_3283 | TRAP transporter small transmembrane protein (tripartite ATP-independent periplasmic transporter; DctQ component). | TRAP transporter (tripartite ATP-independent periplasmic transporter), small transmembrane protein (DctQ component), substrate unknown. | 0.518 |
HELO_3707 | teaA | HELO_3707 | HELO_4274 | TRAP transporter small transmembrane protein (tripartite ATP-independent periplasmic transporter; DctQ component). | TRAP transporter substrate-binding protein TeaA (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Binds ectoine with high affinity. Affinity for hydroxyectoine is approximately 20-fold lower. | 0.764 |
HELO_3707 | teaC | HELO_3707 | HELO_4276 | TRAP transporter small transmembrane protein (tripartite ATP-independent periplasmic transporter; DctQ component). | TRAP transporter large transmembrane protein TeaC (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Belongs to the TRAP transporter large permease family. | 0.789 |
doeA | ectD | HELO_3665 | HELO_4008 | Ectoine hydrolase; Involved in the biosynthesis of ectoine ((S)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the hydrolysis of ectoine to N-acetyl-L-2,4-diaminobutyric acid (N-Ac-DABA). It can produce both isoforms N-gamma-acetyl-L-2,4- diaminobutyric acid (N-gamma-Ac-DABA) and N-alpha-acetyl-L-2,4- diaminobutyric acid (-Nalpha-Ac-DABA), however N-alpha-A [...] | Ectoine hydroxylase; Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2- oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine. | 0.967 |
doeA | teaA | HELO_3665 | HELO_4274 | Ectoine hydrolase; Involved in the biosynthesis of ectoine ((S)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the hydrolysis of ectoine to N-acetyl-L-2,4-diaminobutyric acid (N-Ac-DABA). It can produce both isoforms N-gamma-acetyl-L-2,4- diaminobutyric acid (N-gamma-Ac-DABA) and N-alpha-acetyl-L-2,4- diaminobutyric acid (-Nalpha-Ac-DABA), however N-alpha-A [...] | TRAP transporter substrate-binding protein TeaA (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Binds ectoine with high affinity. Affinity for hydroxyectoine is approximately 20-fold lower. | 0.580 |
doeA | teaB | HELO_3665 | HELO_4275 | Ectoine hydrolase; Involved in the biosynthesis of ectoine ((S)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the hydrolysis of ectoine to N-acetyl-L-2,4-diaminobutyric acid (N-Ac-DABA). It can produce both isoforms N-gamma-acetyl-L-2,4- diaminobutyric acid (N-gamma-Ac-DABA) and N-alpha-acetyl-L-2,4- diaminobutyric acid (-Nalpha-Ac-DABA), however N-alpha-A [...] | TRAP transporter small transmembrane protein TeaB (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Belongs to the TRAP transporter small permease family. | 0.632 |
doeA | teaC | HELO_3665 | HELO_4276 | Ectoine hydrolase; Involved in the biosynthesis of ectoine ((S)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the hydrolysis of ectoine to N-acetyl-L-2,4-diaminobutyric acid (N-Ac-DABA). It can produce both isoforms N-gamma-acetyl-L-2,4- diaminobutyric acid (N-gamma-Ac-DABA) and N-alpha-acetyl-L-2,4- diaminobutyric acid (-Nalpha-Ac-DABA), however N-alpha-A [...] | TRAP transporter large transmembrane protein TeaC (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Belongs to the TRAP transporter large permease family. | 0.584 |
ectD | doeA | HELO_4008 | HELO_3665 | Ectoine hydroxylase; Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2- oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine. | Ectoine hydrolase; Involved in the biosynthesis of ectoine ((S)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the hydrolysis of ectoine to N-acetyl-L-2,4-diaminobutyric acid (N-Ac-DABA). It can produce both isoforms N-gamma-acetyl-L-2,4- diaminobutyric acid (N-gamma-Ac-DABA) and N-alpha-acetyl-L-2,4- diaminobutyric acid (-Nalpha-Ac-DABA), however N-alpha-A [...] | 0.967 |
ectD | teaA | HELO_4008 | HELO_4274 | Ectoine hydroxylase; Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2- oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine. | TRAP transporter substrate-binding protein TeaA (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Binds ectoine with high affinity. Affinity for hydroxyectoine is approximately 20-fold lower. | 0.543 |
mip | teaA | HELO_4278 | HELO_4274 | Macrophage infectivity potentiator; Outer membrane protein MIP precursor - Legionella pneumophila (strain Corby),InterPro: DNA repair protein RecN, High confidence in function and specificity. | TRAP transporter substrate-binding protein TeaA (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Binds ectoine with high affinity. Affinity for hydroxyectoine is approximately 20-fold lower. | 0.633 |
mip | teaB | HELO_4278 | HELO_4275 | Macrophage infectivity potentiator; Outer membrane protein MIP precursor - Legionella pneumophila (strain Corby),InterPro: DNA repair protein RecN, High confidence in function and specificity. | TRAP transporter small transmembrane protein TeaB (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Belongs to the TRAP transporter small permease family. | 0.715 |
mip | teaC | HELO_4278 | HELO_4276 | Macrophage infectivity potentiator; Outer membrane protein MIP precursor - Legionella pneumophila (strain Corby),InterPro: DNA repair protein RecN, High confidence in function and specificity. | TRAP transporter large transmembrane protein TeaC (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Belongs to the TRAP transporter large permease family. | 0.742 |
mip | teaD | HELO_4278 | HELO_4277 | Macrophage infectivity potentiator; Outer membrane protein MIP precursor - Legionella pneumophila (strain Corby),InterPro: DNA repair protein RecN, High confidence in function and specificity. | Regulatory protein TeaD; ATP-binding protein that negatively regulates activity of the tripartite ATP-independent periplasmic (TRAP) ectoine transport system TeaABC. May regulate uptake according to the ATP status of the cell. | 0.777 |
pcoA | teaA | HELO_1864 | HELO_4274 | Copper-resistance protein, CopA family; Copper resistance protein A precursor - Escherichia coli,InterPro: Copper-resistance protein CopA, High confidence in function and specificity. | TRAP transporter substrate-binding protein TeaA (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Binds ectoine with high affinity. Affinity for hydroxyectoine is approximately 20-fold lower. | 0.547 |
teaA | HELO_3283 | HELO_4274 | HELO_3283 | TRAP transporter substrate-binding protein TeaA (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Binds ectoine with high affinity. Affinity for hydroxyectoine is approximately 20-fold lower. | TRAP transporter (tripartite ATP-independent periplasmic transporter), small transmembrane protein (DctQ component), substrate unknown. | 0.481 |
teaA | HELO_3707 | HELO_4274 | HELO_3707 | TRAP transporter substrate-binding protein TeaA (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Binds ectoine with high affinity. Affinity for hydroxyectoine is approximately 20-fold lower. | TRAP transporter small transmembrane protein (tripartite ATP-independent periplasmic transporter; DctQ component). | 0.764 |
teaA | doeA | HELO_4274 | HELO_3665 | TRAP transporter substrate-binding protein TeaA (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Binds ectoine with high affinity. Affinity for hydroxyectoine is approximately 20-fold lower. | Ectoine hydrolase; Involved in the biosynthesis of ectoine ((S)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the hydrolysis of ectoine to N-acetyl-L-2,4-diaminobutyric acid (N-Ac-DABA). It can produce both isoforms N-gamma-acetyl-L-2,4- diaminobutyric acid (N-gamma-Ac-DABA) and N-alpha-acetyl-L-2,4- diaminobutyric acid (-Nalpha-Ac-DABA), however N-alpha-A [...] | 0.580 |