STRINGSTRING
jag1b jag1b notch1a notch1a notch1b notch1b notch3 notch3 notch2 notch2 jag1a jag1a jag2b jag2b rbpja rbpja hey1 hey1 maml1 maml1 zmp:0000001236 zmp:0000001236
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
jag1bProtein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa)    
Predicted Functional Partners:
notch1a
Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]
   
0.999
notch1b
Notch receptor 1b.
   
0.990
notch3
Notch receptor 3.
   
0.975
notch2
Notch receptor 2.
   
0.961
jag1a
Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions.
  
 
0.908
jag2b
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
  
  
0.907
rbpja
Recombination signal-binding protein for immunoglobulin kappa J region a.
    
 
 0.879
hey1
Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family.
   
 
 0.864
maml1
Mastermind-like transcriptional coactivator 1.
    
 
 0.763
zmp:0000001236
MamL-1 domain-containing protein.
    
 
 0.760
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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