STRINGSTRING
yes1 yes1 fyna fyna fynb fynb ctnnd1 ctnnd1 fer fer pik3ca pik3ca kras kras pik3r1 pik3r1 stat1a stat1a cbl cbl grb2b grb2b
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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yes1Tyrosine-protein kinase yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis (By similarity). Required for convergent extension cell movements during gastrulation, acting with fyna via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. During embryonic development, phosphorylates ptk2.1/fak. (546 aa)    
Predicted Functional Partners:
fyna
Tyrosine-protein kinase fyna; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in cntn1-mediated signaling (By similarity). Required for convergent extension cell movements during gastrulation, acting with yes via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling.
  
0.923
fynb
Tyrosine-protein kinase fynb; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling (By similarity).
  
0.922
ctnnd1
Catenin (cadherin-associated protein), delta 1.
    
 0.912
fer
Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
   
 
0.911
pik3ca
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
    
 0.689
kras
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.
   
 0.667
pik3r1
Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).
   
 0.654
stat1a
Signal transducer and activator of transcription.
   
 0.653
cbl
Cbl proto-oncogene, E3 ubiquitin protein ligase.
    
 0.653
grb2b
Growth factor receptor-bound protein 2b.
   
0.639
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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