STRINGSTRING
irx5b irx5b lpcat2 lpcat2 polr2c polr2c irx3a irx3a tbx2a tbx2a hhex hhex dlx1a dlx1a ppargc1a ppargc1a dlx2a dlx2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
irx5bIroquois homeobox 5b. (371 aa)    
Predicted Functional Partners:
lpcat2
Lysophosphatidylcholine acyltransferase 2; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. May catalyze the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3- phosphocholine. May also cataylze the conversion of as well 1-O-alkyl- sn-glycero-3-phosphocholine to 1-O-alkyl-2-acetyl-sn-glycero-3- phosphocholine and 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (By similarity).
      
 0.744
polr2c
Polymerase (RNA) II (DNA directed) polypeptide C.
   
  
 0.560
irx3a
Iroquois 3 homeobox protein.
  
  
0.557
tbx2a
T-box transcription factor 2a.
   
  
 0.537
hhex
Hematopoietically-expressed homeobox protein hhex; Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Plays a role in embryonic dorsoventral patterning by regulating bmp expression. May establish anterior identity. Functions in the embryo to regulate liver development. Functions extraembryonically to generate organ chirality.
   
 
 0.465
dlx1a
Homeobox protein Dlx1a.
    
 
 0.462
ppargc1a
Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
   
  
 0.453
dlx2a
Homeobox protein Dlx2a; Involved in the development of the inner ear; Belongs to the distal-less homeobox family.
   
 
 0.426
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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