STRINGSTRING
rfx2 rfx2 foxj1a foxj1a mcidas mcidas atr atr ift88 ift88 hdx hdx ttc25 ttc25 foxj1b foxj1b chek2 chek2 ccno ccno e2f4 e2f4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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rfx2DNA-binding protein RFX2; Transcription factor that acts as a key regulator of ciliogenesis. Specifically regulates expression of genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (By similarity). Belongs to the RFX family. (734 aa)    
Predicted Functional Partners:
foxj1a
Forkhead box protein J1-A; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Its activity is sufficient for ectopic development of cilia that resemble motile cilia.
   
 
 0.954
mcidas
Uncharacterized protein.
      
 0.861
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
   
 
 0.771
ift88
Intraflagellar transport 88 homolog.
    
 
 0.726
hdx
Highly divergent homeobox.
      
 0.720
ttc25
Tetratricopeptide repeat protein 25; Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility.
   
 
 0.688
foxj1b
Forkhead box protein J1-B; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Belongs to the FOXJ1 family.
   
 
 0.620
chek2
Checkpoint kinase 2.
    
 
 0.601
ccno
CYCLIN domain-containing protein; Belongs to the cyclin family.
   
  
 0.575
e2f4
E2F transcription factor 4.
      
 0.569
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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