STRINGSTRING
s1pr2 s1pr2 sphk2 sphk2 SPHK1 SPHK1 spns2 spns2 gna12a gna12a mbtps1 mbtps1 abcc1 abcc1 rhoab rhoab gnaq gnaq fn1a fn1a ccn2a ccn2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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s1pr2Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). (370 aa)    
Predicted Functional Partners:
sphk2
Sphingosine kinase 2.
      
 0.953
SPHK1
Sphingosine kinase 1.
      
 0.849
spns2
Protein spinster homolog 2; Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in regulating heart development. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration ; Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
      
 0.833
gna12a
Guanine nucleotide-binding protein (G protein) alpha 12a.
    
 
 0.761
mbtps1
Membrane-bound transcription factor peptidase, site 1.
    
 
 0.744
abcc1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1.
      
 0.733
rhoab
Rho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
    
 
 0.612
gnaq
Guanine nucleotide-binding protein (G protein), q polypeptide.
    
 
 0.586
fn1a
Fibronectin 1a.
   
  
 0.569
ccn2a
Novel protein similar to vertebrate connective tissue growth factor (CTGF).
      
 0.540
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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