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ch25h ch25h cyp7b1 cyp7b1 cyp7a1 cyp7a1 cyp7a1b cyp7a1b dhcr7 dhcr7 cyp51 cyp51 sc5d sc5d dhcr24 dhcr24 cyp46a1.1 cyp46a1.1 sqlea sqlea cyp46a1.2 cyp46a1.2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ch25hCholesterol 25-hydroxylase-like protein; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25- hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol reg [...] (251 aa)    
Predicted Functional Partners:
cyp7b1
Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.
   
 0.990
cyp7a1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
   
 0.981
cyp7a1b
Uncharacterized protein.
   
 0.965
dhcr7
7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).
   
 0.955
cyp51
Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
   
 0.949
sc5d
Sterol-C5-desaturase; Belongs to the sterol desaturase family.
   
 
 0.938
dhcr24
24-dehydrocholesterol reductase.
   
 
 0.917
cyp46a1.1
Cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 1; Belongs to the cytochrome P450 family.
   
 0.904
sqlea
Squalene epoxidase a.
   
 
 0.878
cyp46a1.2
Cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 2.
   
 0.851
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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