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insm1b insm1b pkdcca pkdcca neurod1 neurod1 neurod4 neurod4 neurod6b neurod6b kdm1a kdm1a arl4ab arl4ab neurod6a neurod6a myt1b myt1b nkx6.1 nkx6.1 arxa arxa
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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insm1bInsulinoma-associated protein 1b; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity). (453 aa)    
Predicted Functional Partners:
pkdcca
Protein kinase domain-containing, cytoplasmic a.
      
 0.713
neurod1
Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.
   
 
 0.597
neurod4
Neurogenic differentiation factor.
   
 
 0.566
neurod6b
Neurogenic differentiation factor 6-B; Differentiation factor required for neurogenesis (By similarity). Does not act as an upstream activator of isl1.
   
 
 0.563
kdm1a
Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.
   
 
 0.561
arl4ab
ADP-ribosylation factor-like 4, like.
      
 0.551
neurod6a
Neurogenic differentiation factor 6-A; Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.
   
 
 0.548
myt1b
Myelin transcription factor 1b.
      
 0.540
nkx6.1
NK6 homeobox 1.
   
  
 0.537
arxa
Aristaless-related homeobox protein; Appears to be indispensable for the central nervous system development. May have a role in the neuronal differentiation of the ganglionic eminence and ventral thalamus. May also be involved in axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily.
   
  
 0.517
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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